Research Progress in Isolation and Enrichment of Fetal Cells from Maternal Blood

被引：6

作者：

Tang, Ying ^{[1
,2
,3
]}

Tang, Qiaojin ^{[4
]}

Luo, Haiyan ^{[1
]}

Zhang, Xuehui ^{[5
]}

Chen, Qiuyu ^{[4
]}

Tang, Wenying ^{[1
,2
,3
]}

Wang, Ting ^{[1
,2
,3
]}

Yang, Lihua ^{[6
]}

Liao, Hongwu ^{[1
,2
,3
]}

机构：

[1] Univ South China, Affiliated Nanhua Hosp, Hengyang Med Sch, Hengyang 421002, Hunan, Peoples R China

[2] Univ South China, Hengyang Med Sch, Sch Nursing, Hengyang 421002, Hunan, Peoples R China

[3] Univ South China, Affiliated Nanhua Hosp, Hlth Sch Nucl Ind, Hengyang Med Sch, Hengyang 421002, Hunan, Peoples R China

[4] Univ South China, Affiliated Nanhua Hosp, Dept Gynecol & Matern, Hengyang Med Sch, Hengyang 421002, Hunan, Peoples R China

[5] Hengyang Maternal & Child Hlth Care Hosp, Hengyang 421001, Hunan, Peoples R China

[6] Xiangnan Univ, Affiliated Hosp, Chenzhou 423000, Hunan, Peoples R China

来源：

JOURNAL OF CHEMISTRY | 2022年 / 2022卷

关键词：

PRENATAL-DIAGNOSIS; PERIPHERAL-BLOOD; DNA; IDENTIFICATION; ANEUPLOIDIES;

D O I：

10.1155/2022/7131241

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Prenatal diagnosis is an important means of early diagnosis of genetic diseases, which can effectively reduce the risk of birth defects. Free fetal cells, as a carrier of intact fetal genetic material, provide hope for the development of high-sensitivity and high-accuracy prenatal diagnosis technology. However, the number of fetal cells is small and it is difficult to apply clinically. In recent years, noninvasive prenatal diagnosis (NIPD) technology for fetal genetic material in maternal peripheral blood has developed rapidly, which makes it possible to diagnose genetic diseases by fetal cells in maternal peripheral blood. This article reviewed the current status of fetal cell separation and enrichment technology and its application in noninvasive prenatal diagnosis technology.

引用

页数：8

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