Probiotics and gut microbiome-Prospects and challenges in remediating heavy metal toxicity

被引:102
作者
Arun, K. B. [1 ]
Madhavan, Aravind [1 ]
Sindhu, Raveendran [2 ]
Emmanual, Shibitha [3 ]
Binod, Parameswaran [2 ]
Pugazhendhi, Arivalagan [4 ,5 ]
Sirohi, Ranjna [6 ,11 ]
Reshmy, R. [7 ]
Awasthi, Mukesh Kumar [8 ]
Gnansounou, Edgard [9 ]
Pandey, Ashok [10 ,11 ]
机构
[1] Rajiv Gandhi Ctr Biotechnol, Trivandrum 695014, Kerala, India
[2] CSIR, Microbial Proc & Technol Div, Natl Inst Interdisciplinary Sci & Technol, Trivandrum 695019, Kerala, India
[3] St Josephs Coll, Dept Zool, Trichur 680121, Kerala, India
[4] Maejo Univ, Sch Renewable Energy, Chiang Mai 50290, Thailand
[5] Asia Univ, Coll Med & Hlth Sci, Taichung, Taiwan
[6] Korea Univ, Dept Chem & Biol Engn, Seoul 136713, South Korea
[7] Bishop Moore Coll, Post Grad & Res Dept Chem, Mavelikara 690110, Kerala, India
[8] North West A&F Univ, Coll Nat Resources & Environm, Yangling 712100, Shaanxi, Peoples R China
[9] Ecole Polytech Fed Lausanne, ENAC GR GN, CH-1015 Lausanne, Switzerland
[10] CSIR, Indian Inst Toxicol Res, Ctr Innovat & Translat Res, Lucknow 226001, Uttar Pradesh, India
[11] Ctr Energy & Environm Sustainabil, Lucknow 226029, Uttar Pradesh, India
关键词
Gut microbiome; Heavy metals; Heavy metal toxicity; Detoxification; Next-generation probiotics; INFLAMMATORY-BOWEL-DISEASE; ESCHERICHIA-COLI CHALLENGE; ARYL-HYDROCARBON RECEPTOR; INDUCED OXIDATIVE STRESS; LACTIC-ACID BACTERIA; HUMAN HEALTH; INTESTINAL MICROBIOTA; CADMIUM ABSORPTION; SURFACE BINDING; KIDNEY-DISEASE;
D O I
10.1016/j.jhazmat.2021.126676
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
The gut microbiome, often referred to as "super organ", comprises up to a hundred trillion microorganisms, and the species diversity may vary from person to person. They perform a decisive role in diverse biological functions related to metabolism, immunity and neurological responses. However, the microbiome is sensitive to environmental pollutants, especially heavy metals. There is continuous interaction between heavy metals and the microbiome. Heavy metal exposure retards the growth and changes the structure of the phyla involved in the gut microbiome. Meanwhile, the gut microbiome tries to detoxify the heavy metals by altering the physiological conditions, intestinal permeability, enhancing enzymes for metabolizing heavy metals. This review summarizes the effect of heavy metals in altering the gut microbiome, the mechanism by which gut microbiota detoxifies heavy metals, diseases developed due to heavy metal-induced dysbiosis of the gut microbiome, and the usage of probiotics along with advancements in developing improved recombinant probiotic strains for the remediation of heavy metal toxicity.
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页数:19
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