Molecular and Biological Functions of Melatonin in Endometrial Cancer

被引：16

作者：

Dana, Parisa Maleki ^{[1
]}

Sadoughi, Fatemeh ^{[1
]}

Mobini, Moein ^{[2
]}

Shafabakhsh, Rana ^{[1
]}

Chaichian, Shala ^{[3
]}

Moazzami, Bahram ^{[3
]}

Chamani, Maryam ^{[4
]}

Asemi, Zatollah ^{[1
]}

机构：

[1] Kashan Univ Med Sci, Res Ctr Biochem & Nutr Metab Dis, Kashan, Iran

[2] Univ Calgary, Fac Kinesiol, Calgary, AB, Canada

[3] Iran Univ Med Sci, Pars Hosp, Pars Adv & Minimally Invas Med Manners Res Ctr, Tehran, Iran

[4] Iran Univ Med Sci, Sch Med, Dept Gynecol & Obstet, Tehran, Iran

来源：

CURRENT DRUG TARGETS | 2020年 / 21卷 / 05期

关键词：

Melatonin; pregnancy; endometrial cancer; apoptosis; obesity; bone marrow; ENDOTHELIAL GROWTH-FACTOR; BREAST-CANCER; PINEAL-GLAND; CELL-DEATH; EXPRESSION PATTERN; OXIDATIVE STRESS; RECEPTOR; RISK; ANGIOGENESIS; PROLIFERATION;

D O I：

10.2174/1389450120666190927123746

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Endometrial cancer is the fifth leading cancer among women. This rate is higher in developed countries and its incidence is increasing worldwide. Diabetes mellitus, obesity, hypertension and arteriosclerosis are major risk factors for endometrial cancer. Melatonin is a hormone synthesized in the pineal and extra-pineal organs such as the digestive tract, bone marrow, retina and more. Evidence shows the potential effects of melatonin in endometrial cancer inhibition. Therefore, the focus of this paper is to review this outstanding evidence and to summarize the molecular and biological mechanisms of melatonin for the inhibition of endometrial cancer.

引用

页码：519 / 526

页数：8

共 101 条

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