Synthesis and Anticonvulsive Activity of 5-Pyrrolidin-1-Ylpyrano[4aEuro3,3aEuro3:4',5']Pyrido-3',2':4,5]Thieno[3,2-D]Pyrimidine Derivatives

被引：3

作者：

Dashyan, Sh. Sh. ^{[1
]}

Paronikyan, E. G. ^{[1
]}

Noravyan, A. S. ^{[1
]}

Paronikyan, R. G. ^{[1
]}

机构：

[1] Natl Acad Sci Republ Armenia, Sci & Technol Ctr Organ & Pharmaceut Chem, Inst Fine Organ Chem, Yerevan, Armenia

来源：

PHARMACEUTICAL CHEMISTRY JOURNAL | 2016年 / 50卷 / 04期

关键词：

alkoxypyrido[2,3-b]thieno[3,2-d]pyrimidines; aminopyrido[2,3-b]thieno[3,2-d]pyrimidines; alkylsulfanylpyrido[2,3-b]thieno[3,2-d]pyrimidines; ethosuximide; anticonvulsive activity; BIOLOGICAL-ACTIVITY;

D O I：

10.1007/s11094-016-1426-x

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A method for preparing the amino, alkoxy, and alkylsulfanyl derivatives of pyrano[4aEuro(3),3aEuro(3):4',5']pyrido-[3',2':4,5]thieno[3,2-d]pyrimidines based on 8-chloro-2,2-dimethyl-5-pyrrolidin-1-yl-1,4-dihydro-2H-pyrano[4aEuro(3),3aEuro(3):4',5']pyrido[3',2':4,5]thieno[3,2-d]pyrimidine was developed. The anticonvulsant activity of the compounds synthesized here was investigated.

引用

页码：221 / 225

页数：5

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