Incorporation of positively charged deoxynucleic S-methylthiourea linkages into oligodeoxyribonucleotides

被引：13

作者：

Challa, H ^{[1
]}

Bruice, TC ^{[1
]}

机构：

[1] Univ Calif Santa Barbara, Dept Chem & Biochem, Santa Barbara, CA 93106 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 18期

关键词：

D O I：

10.1016/S0960-894X(01)00455-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Oligodeoxyribonucleic acids (15- and 18-mers) containing both negatively charged phosphate and positively charged S-methyl thiourea internucleoside linkages (DNmt/DNA chimera) have been synthesized. DNA binding characteristics and nuclease resistance of DNmt/DNA chimera have been evaluated. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：2423 / 2427

页数：5

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