Corpus callosum atrophy as a predictor of age-related cognitive and motor impairment: A 3-year follow-up of the LADIS study cohort

被引：59

作者：

Ryberg, C. ^{[2
]}

Rostrup, E. ^{[2
]}

Paulson, O. B. ^{[2
,3
]}

Barkhof, F. ^{[4
,5
]}

Scheltens, P. ^{[6
]}

van Straaten, E. C. W. ^{[6
]}

van der Flier, W. M. ^{[6
]}

Fazekas, F. ^{[7
]}

Schmidt, R. ^{[7
]}

Ferro, J. M. ^{[8
]}

Baezner, H. ^{[9
]}

Erkinjuntti, T. ^{[10
]}

Jokinen, H. ^{[10
]}

Wahlund, L-O ^{[11
]}

Poggesi, A. ^{[12
]}

Pantoni, L. ^{[12
]}

Inzitari, D. ^{[12
]}

Waldemar, G. ^{[1
]}

机构：

[1] Copenhagen Univ Hosp, Rigshosp, Dept Neurol, Memory Disorders Res Grp,Sect 2082, DK-2100 Copenhagen, Denmark

[2] Copenhagen Univ Hosp, Danish Res Ctr Magnet Resonance, Hvidovre, Denmark

[3] Copenhagen Univ Hosp, Rigshosp, Neurobiol Res Unit, DK-2100 Copenhagen, Denmark

[4] Vrije Univ Amsterdam Med Ctr, Dept Radiol, Amsterdam, Netherlands

[5] Vrije Univ Amsterdam Med Ctr, Image Anal Ctr, Amsterdam, Netherlands

[6] Vrije Univ Amsterdam Med Ctr, Dept Neurol, Amsterdam, Netherlands

[7] Med Univ, Dept Neurol, Graz, Austria

[8] Hosp Santa Maria, Serv Neurol, Ctr Estudos Egas Moniz, Lisbon, Portugal

[9] Univ Med Mannheim, Univ Heidelberg, Dept Neurol, D-6800 Mannheim, Germany

[10] Univ Helsinki, Dept Neurol, Memory Res Unit, FIN-00014 Helsinki, Finland

[11] Karolinska Inst, Huddinge Univ Hosp, Dept Clin Neurosci, NEUROTEC, Stockholm, Sweden

[12] Univ Florence, Dept Neurol & Psychiat Sci, Florence, Italy

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 2011年 / 307卷 / 1-2期

关键词：

Corpus callosum; Age-related white matter changes; Motor function; Cognition; Dementia; Elderly; Follow-up study; LADIS; WHITE-MATTER HYPERINTENSITIES; ALZHEIMERS-DISEASE; REGIONAL ATROPHY; DISABILITY; TOPOGRAPHY; DEMENTIA; IMPACT;

D O I：

10.1016/j.jns.2011.05.002

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The aim of this 3-year follow-up study was to investigate whether corpus callosum (CC) atrophy may predict future motor and cognitive impairment in an elderly population. On baseline MRI from 563 subjects with age-related white matter changes (ARWMC) from the Leukoaraiosis And DISability (LADIS) study, the CC was segmented and subdivided into five anterior-posterior regions (CC1-CC5). Associations between the CC areas and decline in motor performance and cognitive functions over a 3-year period were analyzed. CC atrophy at baseline was significantly associated with impaired cognitive performance ( p < 0.01 for CC1, p < 0.05 for CC5), motor function (p<0.05 for CC2 and CC5), and walking speed (p<0.01 for CC2 and CC5, p < 0.05 for CC3 and total CC), and with development of dementia at 3 years (p<0.05 for CC1) after correction for appropriate confounders (ARWMC volume, atrophy, age, gender and handedness). In conclusion, CC atrophy, an indicator of reduced functional connectivity between cortical areas, seems to contribute, independently of ARWMC load, to future cognitive and motor decline in the elderly. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：100 / 105

页数：6

共 32 条

[1]

[Anonymous], 1994, AM PSYCHIATR ASSOC

[2] The role of the corpus callosum in interhemispheric transfer of information: Excitation or inhibition? [J].

Bloom, JS ;

Hynd, GW .

NEUROPSYCHOLOGY REVIEW, 2005, 15 (02) :59-71

[3] Biomarkers for Alzheimer's disease and other forms of dementia: Clinical needs, limitations and future aspects [J].

Cedazo-Minguez, Angel ;

Winblad, Bengt .

EXPERIMENTAL GERONTOLOGY, 2010, 45 (01) :5-14

[4] Active appearance models [J].

Cootes, TF ;

Edwards, GJ ;

Taylor, CJ .

IEEE TRANSACTIONS ON PATTERN ANALYSIS AND MACHINE INTELLIGENCE, 2001, 23 (06) :681-685

[5] TOPOGRAPHY OF THE HUMAN CORPUS-CALLOSUM [J].

DELACOSTE, MC ;

KIRKPATRICK, JB ;

ROSS, ED .

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 1985, 44 (06) :578-591

[6] MINI-MENTAL STATE - PRACTICAL METHOD FOR GRADING COGNITIVE STATE OF PATIENTS FOR CLINICIAN [J].

FOLSTEIN, MF ;

FOLSTEIN, SE ;

MCHUGH, PR .

JOURNAL OF PSYCHIATRIC RESEARCH, 1975, 12 (03) :189-198

[7] A SHORT PHYSICAL PERFORMANCE BATTERY ASSESSING LOWER-EXTREMITY FUNCTION - ASSOCIATION WITH SELF-REPORTED DISABILITY AND PREDICTION OF MORTALITY AND NURSING-HOME ADMISSION [J].

GURALNIK, JM ;

SIMONSICK, EM ;

FERRUCCI, L ;

GLYNN, RJ ;

BERKMAN, LF ;

BLAZER, DG ;

SCHERR, PA ;

WALLACE, RB .

JOURNALS OF GERONTOLOGY, 1994, 49 (02) :M85-M94

[8] White matter abnormalities in mobility-impaired older persons [J].

Guttmann, CRG ;

Benson, R ;

Warfield, SK ;

Wei, X ;

Anderson, MC ;

Hall, CB ;

Abu-Hasaballah, K ;

Mugler, JP ;

Wolfson, L .

NEUROLOGY, 2000, 54 (06) :1277-1283

[9] Regional atrophy of the corpus callosum in dementia [J].

Hallam, Bradley J. ;

Brown, Warren S. ;

Ross, Chris ;

Buckwalter, J. Galen ;

Bigler, Erin D. ;

Tschanz, Joann T. ;

Norton, Maria C. ;

Welsh-Bohmer, Kathleen A. ;

Breitner, John C. S. .

JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY, 2008, 14 (03) :414-423

[10] In vivo imaging of region and cell type specific neocortical neurodegeneration in Alzheimer's disease -: Perspectives of MRI derived corpus callosum measurement for mapping disease progression and effects of therapy.: Evidence from studies with MRI, EEG and PET [J].

Hampel, H ;

Teipel, SJ ;

Alexander, GE ;

Pogarell, O ;

Rapoport, SI ;

Möller, HJ .

JOURNAL OF NEURAL TRANSMISSION, 2002, 109 (5-6) :837-855

← 1 2 3 4 →