Non-immune hydrops fetalis: A short review of etiology and pathophysiology

被引：116
作者：
Bellini, Carlo [1 ]
Hennekam, Raoul C. M. [2 ,3 ]
机构：
[1] Univ Genoa, Dept Paediat, Neonatal Intens Care Unit, Gaslini Inst,IRCCS G Gaslini, I-16147 Genoa, Italy
[2] Univ Amsterdam, Acad Med Ctr, Dept Paediat, NL-1105 AZ Amsterdam, Netherlands
[3] Univ Amsterdam, Acad Med Ctr, Dept Translat Genet, NL-1105 AZ Amsterdam, Netherlands
来源：
AMERICAN JOURNAL OF MEDICAL GENETICS PART A | 2012年 / 158A卷 / 03期
关键词：
non-immune hydrops fetalis; fetal hydrops; pathogenesis; edema of the fetus; NIHF; pathophysiologic pathways; AMNIOTIC-FLUID VOLUME; OUTFLOW PRESSURE; UMBILICAL-CORD; WATER; PHYSIOLOGY; PLACENTA; ASPHYXIA; BRAIN; FETUS; AQUAPORINS;
D O I：
10.1002/ajmg.a.34438
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Hydrops fetalis is an excessive accumulation of fetal fluid. Hydrops is traditionally classified into either immune or non-immune hydrops (NIHF), but in practice, nowadays in the Western world >90% of hydrops is of non-immune origin. The basis of the disorder is an imbalance in the regulation of fetal fluid movement between the vascular and interstitial space. We previously suggested a diagnostic flow-chart for NIHF. In this short review we describe the main mechanisms leading to NIHF. (c) 2012 Wiley Periodicals, Inc.
引用
收藏
页码：597 / 605
页数：9
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