Non-immune hydrops fetalis: A short review of etiology and pathophysiology

被引：116

作者：

Bellini, Carlo ^{[1
]}

Hennekam, Raoul C. M. ^{[2
,3
]}

机构：

[1] Univ Genoa, Dept Paediat, Neonatal Intens Care Unit, Gaslini Inst,IRCCS G Gaslini, I-16147 Genoa, Italy

[2] Univ Amsterdam, Acad Med Ctr, Dept Paediat, NL-1105 AZ Amsterdam, Netherlands

[3] Univ Amsterdam, Acad Med Ctr, Dept Translat Genet, NL-1105 AZ Amsterdam, Netherlands

来源：

AMERICAN JOURNAL OF MEDICAL GENETICS PART A | 2012年 / 158A卷 / 03期

关键词：

non-immune hydrops fetalis; fetal hydrops; pathogenesis; edema of the fetus; NIHF; pathophysiologic pathways; AMNIOTIC-FLUID VOLUME; OUTFLOW PRESSURE; UMBILICAL-CORD; WATER; PHYSIOLOGY; PLACENTA; ASPHYXIA; BRAIN; FETUS; AQUAPORINS;

D O I：

10.1002/ajmg.a.34438

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Hydrops fetalis is an excessive accumulation of fetal fluid. Hydrops is traditionally classified into either immune or non-immune hydrops (NIHF), but in practice, nowadays in the Western world >90% of hydrops is of non-immune origin. The basis of the disorder is an imbalance in the regulation of fetal fluid movement between the vascular and interstitial space. We previously suggested a diagnostic flow-chart for NIHF. In this short review we describe the main mechanisms leading to NIHF. (c) 2012 Wiley Periodicals, Inc.

引用

页码：597 / 605

页数：9

共 41 条

[1] Aquaporin water channels (Nobel lecture) [J].

Agre, P .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2004, 43 (33) :4278-4290

[2]

AGRE P, 1993, AM J PHYSIOL, V265, pF463

[3] AQUAPORINS - A FAMILY OF WATER CHANNEL PROTEINS [J].

AGRE, P ;

SASAKI, S ;

CHRISPEELS, MJ .

AMERICAN JOURNAL OF PHYSIOLOGY, 1993, 265 (03) :F461-F461

[4] Pathophysiology of hydrops fetalis [J].

Apkon, M .

SEMINARS IN PERINATOLOGY, 1995, 19 (06) :437-446

[5]

Bellini C, 2006, LYMPHOLOGY, V39, P110

[6] Immunohistochemistry in Non-Immune Hydrops Fetalis: A Single Center Experience in 79 Fetuses [J].

Bellini, Carlo ;

Fulcheri, Ezio ;

Rutigliani, Mariangela ;

Calevo, Maria Grazia ;

Boccardo, Francesco ;

Campisi, Corradino ;

Bonioli, Eugenio ;

Bellini, Tommaso ;

Hennekam, Raoul C. M. .

AMERICAN JOURNAL OF MEDICAL GENETICS PART A, 2010, 152A (05) :1189-1196

[7] Etiology of Nonimmune Hydrops Fetalis: A Systematic Review [J].

Bellini, Carlo ;

Hennekam, Raoul C. M. ;

Fulcheri, Ezio ;

Rutigliani, Mariangela ;

Morcaldi, Guido ;

Boccardo, Francesco ;

Bonioli, Eugenio .

AMERICAN JOURNAL OF MEDICAL GENETICS PART A, 2009, 149A (05) :844-851

[8] A Diagnostic Flow Chart for Non-immune Hydrops Fetalis [J].

Bellini, Carlo ;

Hennekam, Raoul C. M. ;

Bonioli, Eugenio .

AMERICAN JOURNAL OF MEDICAL GENETICS PART A, 2009, 149A (05) :852-853

[9]

Brace R.A., 2004, Fetal and neonatal physiology, V2, P1341

[10] EFFECTS OF OUTFLOW PRESSURE AND VASCULAR VOLUME LOADING ON THORACIC-DUCT LYMPH-FLOW IN ADULT SHEEP [J].

BRACE, RA ;

VALENZUELA, GJ .

AMERICAN JOURNAL OF PHYSIOLOGY, 1990, 258 (01) :R240-R244

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