Fluorinated (hetero)cycles via ring-closing metathesis of fluoride- and trifluoromethyl-functionalized olefins

被引：46
作者：
De Matteis, V
van Delft, FL
de Gelder, R
Tiebes, J
Rutjes, FPJT
机构：
[1] Catholic Univ Nijmegen, NSRIM, Dept Organ Chem, NL-6525 ED Nijmegen, Netherlands
[2] Catholic Univ Nijmegen, NSRIM, Dept Inorgan Chem, NL-6525 ED Nijmegen, Netherlands
[3] Bayer CropSci GmbH, Chem Res, D-65926 Frankfurt, Germany
来源：
TETRAHEDRON LETTERS | 2004年 / 45卷 / 05期
关键词：
D O I：
10.1016/j.tetlet.2003.11.093
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Ring-closing metathesis(RCM) has been shown to be a viable tool to incorporate fluoride and trifluoromethyl substituents in (hetero)cyclic ring systems. 2-Fluoroacrylamides were cyclized to the corresponding lactams, and trifluoromethyl- substituted olefins were cyclized to yield trifluoromethylated cyclopentenes, pyrrolines and a dihydrofuran derivative. (C) 2003 Elsevier Ltd. All rights reserved.
引用
收藏
页码：959 / 963
页数：5
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