Helquinoline, a new tetrahydroquinoline antibiotic from Janibacter limosus Hel 1

被引：92
作者：
Asolkar, RN
Schröder, D
Heckmann, R
Lang, S
Wagner-Döbler, I
Laatsch, H
机构：
[1] Univ Gottingen, Dept Organ Chem, D-37077 Gottingen, Germany
[2] Tech Univ Braunschweig, Inst Biochem & Biotechnol, Dept Biotechnol, D-38106 Braunschweig, Germany
[3] Natl Res Inst Biotechnol, Dept Microbiol, D-38124 Braunschweig, Germany
来源：
JOURNAL OF ANTIBIOTICS | 2004年 / 57卷 / 01期
关键词：
D O I：
10.7164/antibiotics.57.17
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The ethyl acetate extract of cultures of Janibacter limosus showed a high biological activity against bacteria, and fungi and delivered. two new natural products, a tetrahydroquinoline derivative designated as helquinoline (1), and the N-acetylkynuramine (3a), along with other known secondary metabolites. The structure of 1 has been elucidated as 4-methoxy-2-methyl-1,2,3,4-tetrahydroquinoline-8-carboxylic acid on the basis of 1D and 2D NMR and mass spectra. The relative stereochemistry of the compound 1 was assigned as 2R*,4R* with the aid of coupling constants, NOESY correlation and by comparison with a related compound.
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页码：17 / 23
页数：7
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