Molecular Subtypes and Local-Regional Control of Breast Cancer

被引：314

作者：

Fragomeni, Simona Maria ^{[1
]}

Sciallis, Andrew ^{[2
]}

Jeruss, Jacqueline S. ^{[2
,3
]}

机构：

[1] Univ Cattolica Sacro Cuore, Div Gynecol Oncol, Multidisciplinary Breast Ctr, Lgo Agostino Gemelli 8, I-00168 Rome, Italy

[2] Univ Michigan, Dept Pathol, Div Anat Pathol, Ann Arbor, MI 48105 USA

[3] Univ Michigan, Dept Surg, Div Surg Oncol, 1500 East Med Ctr Dr, Ann Arbor, MI 48105 USA

来源：

SURGICAL ONCOLOGY CLINICS OF NORTH AMERICA | 2018年 / 27卷 / 01期

基金：

美国国家卫生研究院;

关键词：

Breast cancer; Molecular subtypes; Local-regional recurrence; Gene signatures; Immunohistochemical surrogates; ESTROGEN-RECEPTOR STATUS; ADJUVANT ENDOCRINE THERAPY; COMPARING TOTAL MASTECTOMY; KI-67 LABELING INDEX; LOCOREGIONAL RECURRENCE; NEOADJUVANT CHEMOTHERAPY; PROGESTERONE-RECEPTOR; CONSERVING THERAPY; PROGNOSTIC-FACTORS; RADIATION-THERAPY;

D O I：

10.1016/j.soc.2017.08.005

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In the era of personalized medicine, there has been significant progress regarding the molecular analysis of breast cancer subtypes. Research efforts have focused on how classification of subtypes could provide information on prognosis and influence treatment planning. Although much is known about the impact of different molecular subtypes on disease-specific survival, more recent studies have investigated the role of the different molecular subtypes on local-regional recurrence. This is an area of active study, and in recent years there has been significant progress. This article describes outcomes among disease subtypes to aid in optimal surgical decision making to improve local-regional control.

引用

页码：95 / 120

页数：26

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