Chronic thromboembolic pulmonary hypertension: anticoagulation and beyond

被引:3
作者
Martin, Karlyn A. [1 ]
Cuttica, Michael J. [2 ,3 ]
机构
[1] Northwestern Univ, Dept Med, Feinberg Sch Med, Div Hematol Oncol, 645 N Michigan Ave,Suite 1020, Chicago, IL 60611 USA
[2] Northwestern Univ, Dept Med, Feinberg Sch Med, Div Pulm & Crit Care Med, Chicago, IL 60611 USA
[3] Northwestern Mem Hosp, Bluhm Cardiovasc Inst, Chicago, IL 60611 USA
关键词
FOLLOW-UP; EMBOLISM; ENDARTERECTOMY; EXPERIENCE; BOSENTAN;
D O I
10.1182/hematology.2021000282
中图分类号
G40 [教育学];
学科分类号
040101 ; 120403 ;
摘要
Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare complication in pulmonary embolism (PE) survivors, characterized by chronic vascular occlusion and pulmonary hypertension. The identification and diagnosis of CTEPH requires a stepwise approach, starting with symptom evaluation, functional evaluation, screening imaging, and progressing to interventional hemodynamic assessment. On the backbone of anticoagulation, CTEPH management necessitates a multidisciplinary approach. Surgical pulmonary thromboendarterectomy (PTE) is the only potentially curative option. In nonoperable disease or residual disease after PTE, interventional balloon pulmonary angioplasty and/or pulmonaryvasodilator therapies can be offered, in collaboration with interventional and vascular pulmonary colleagues. As it is a disease that can cause high morbidity and mortality, CTEPH requires a high index of suspicion to diagnose and treat in patients following PE.
引用
收藏
页码:478 / 484
页数:7
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