Common genetic variation at 15q25.2 impacts on chronic lymphocytic leukaemia risk

被引：18

作者：

Crowther-Swanepoel, Dalemari ^{[1
]}

Di Bernardo, Maria Chiara ^{[1
]}

Jamroziak, Krzysztof ^{[2
]}

Karabon, Lidia ^{[3
]}

Frydecka, Irena ^{[3
]}

Deaglio, Silvia ^{[4
,5
]}

D'Arena, Giovanni ^{[6
]}

Rossi, Davide ^{[7
,8
]}

Gaidano, Gianluca ^{[7
,8
]}

Olver, Bianca ^{[1
]}

Lloyd, Amy ^{[1
]}

Broderick, Peter ^{[1
]}

Laurenti, Luca ^{[9
]}

Szemraj-Rogucka, Zofia ^{[2
]}

Robak, Tadeusz ^{[2
]}

Catovsky, Daniel ^{[10
]}

Houlston, Richard S. ^{[1
]}

机构：

[1] Inst Canc Res, Sect Canc Genet, Sutton SM2 5NG, Surrey, England

[2] Med Univ Lodz, Dept Haematol, Copernicus Mem Hosp, Lodz, Poland

[3] Polish Acad Sci, Inst Immunol & Expt Therapy, PL-53114 Wroclaw, Poland

[4] Univ Turin, Dept Genet Biol & Biochem, Turin, Italy

[5] HuGeF, Turin, Italy

[6] IRCCS Casa Sollievo della Sofferenza Hosp, San Giovanni Rotondo, Italy

[7] Amedeo Avogadro Univ Eastern Piedmont, Div Haematol, Dept Clin & Expt Med, Novara, Italy

[8] Amedeo Avogadro Univ Eastern Piedmont, IRCAD, Novara, Italy

[9] Univ Cattolica Sacro Cuore, Inst Haematol, I-00168 Rome, Italy

[10] Inst Canc Res, Sect Haematooncol, Sutton SM2 5NG, Surrey, England

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2011年 / 154卷 / 02期

关键词：

chronic lymphocytic leukaemia; risk; common variant; CPEB1; ZAP-70; EXPRESSION; CELL-RECEPTOR; IMMUNOGLOBULIN; CPEB;

D O I：

10.1111/j.1365-2141.2011.08706.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A genome-wide association study of chronic lymphocytic leukaemia (CLL) suggested that common variants at 15q25.2 (rs783540) and 18q21.1 (rs1036935) influence CLL. To validate these associations and explore their relationship with CLL risk we genotyped case-control datasets from Poland, UK and Italy totalling 1428 cases and 1920 controls. Combined data from these and previously genotyped series (2503 cases and 5789 controls) provided evidence for an association between 15q25.2 and 18q21.1 loci and CLL risk (P(combined) = 1.10 x 10(-7) and 1.30 x 10(-5) respectively). These data provide further evidence for the involvement of common genetic variants in CLL risk and insight into the biological basis of disease development.

引用

页码：229 / 233

页数：5

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