Elevated Levels of Plasma Superoxide Dismutases 1 and 2 in Patients with Coronary Artery Disease

被引：28

作者：

Peng, Ji-Ren ^{[1
]}

Lu, Ting-Ting ^{[2
]}

Chang, Hao-Teng ^{[3
,4
]}

Ge, Xuan ^{[1
]}

Huang, Bian ^{[1
]}

Li, Wei-Min ^{[1
]}

机构：

[1] Wenzhou Med Univ, Dept Med Cardiol, Affiliated Dongyang Hosp, Dongyang, Zhejiang, Peoples R China

[2] Wenzhou Med Univ, Dept Sci Educ, Affiliated Dongyang Hosp, Dongyang, Zhejiang, Peoples R China

[3] China Med Univ, Grad Inst Biomed Sci, Taichung, Taiwan

[4] Asia Univ, Dept Comp Sci & Informat Engn, Taichung, Taiwan

来源：

BIOMED RESEARCH INTERNATIONAL | 2016年 / 2016卷

关键词：

FAT-FED MICE; FREE-RADICALS; OXIDATIVE STRESS; LIPID-PEROXIDATION; ATHEROSCLEROSIS; ANTIOXIDANTS; COPPER; CHINA; CELLS;

D O I：

10.1155/2016/3708905

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Aims. To measure plasma levels of superoxide dismutases 1, 2, and 3 (SOD1, 2, 3) and determine whether SODs can function as biomarkers for coronary artery disease (CAD). Patients & Methods. Patient groups were as follows: patients with stable angina pectoris (SAP, n = 33), patients with acute coronary syndrome (ACS, n = 49), and controls (n = 42). Protein quantification was done using ELISA. Results. The concentrations of plasma SOD1 and SOD2 were higher in CAD than in healthy controls. No difference in SOD3 levels between CAD and control groups was found. Limited correlations were found between SODs and gender, age, and severity of coronary artery stenosis. Conclusions. Plasma levels of SOD1 and SOD2 were elevated in patients with CAD and might serve as surrogate biomarkers for CAD.

引用

页数：9

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