Severe Inflammation, Acute Kidney Injury, and Drug-Drug Interaction: Triple Penalty for Prolonged Elimination of Apixaban in Patients With Coronavirus Disease 2019: A Grand Round

被引：4

作者：

Launay, Manon ^{[1
]}

Demartin, Anne-Laure ^{[1
]}

Ragey, Sophie Perinel ^{[2
,3
]}

Mismetti, Patrick ^{[4
]}

Botelho-Nevers, Elisabeth ^{[5
]}

Delavenne, Xavier ^{[1
,3
]}

机构：

[1] CHU St Etienne, Lab Pharmacol Toxicol Gaz Sang, St Etienne, France

[2] CHU St Etienne, Serv Med Intens & Reanimat G, St Etienne, France

[3] Univ Lyon, Dysfonct Vasc & Hemostase, INSERM, U1059, St Etienne, France

[4] CHU St Etienne, Serv Med Vasc & Therapeut, St Etienne, France

[5] CHU St Etienne, Infect Dis Dept, St Etienne, France

来源：

THERAPEUTIC DRUG MONITORING | 2021年 / 43卷 / 04期

关键词：

apixaban; lopinavir; COVID-19; inflammation; acute kidney failure; drug-drug interaction; TRANSPORTERS;

D O I：

10.1097/FTD.0000000000000899

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

In this article, we present a case of apixaban elimination prolonged by 450% in a patient with coronavirus disease 2019 because of multiple conditions, including drug-drug interaction, severe inflammation, and acute kidney injury. Therapeutic drug monitoring was used to explain unusual routine coagulation assays. This grand round highlights the importance of dialog between the clinician and a therapeutic drug monitoring consultant for optimal patient care.

引用

页码：455 / 458

页数：4

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