Construction of Carbon-Fluorine Bonds via Copper-Catalyzed/-Mediated Fluorination Reactions

被引:18
作者
Dong, Tao [1 ]
Tsui, Gavin Chit [1 ]
机构
[1] Chinese Univ Hong Kong, Dept Chem, Shatin, Hong Kong, Peoples R China
关键词
copper; fluorination; organofluorine; selectivity; C-F bond; OXIDATIVE FLUORINATION; DIARYLIODONIUM SALTS; ARYL STANNANES; AMINOFLUORINATION; CHEMISTRY; TRIFLUOROMETHYLATION; PHARMACEUTICALS; STRATEGIES; SECONDARY; CATALYSIS;
D O I
10.1002/tcr.202100231
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The construction of carbon-fluorine bonds is an important yet challenging task in organic synthesis. Transition metal-catalyzed/-mediated C-F bond forming processes have recently emerged as a viable strategy and provided access to value-added monofluorinated compounds. A dramatic increase in fluorination methods using inexpensive and earth-abundant copper can be seen in the past decade surpassing those using palladium and silver. This review discusses the recent development of Cu-catalyzed/-mediated formation of C(sp(2))-F and C(sp(3))-F bonds.
引用
收藏
页码:4015 / 4031
页数:17
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