Resistance of human cytomegalovirus to D- and L-ribosyl benzimidazoles as a tool to identify potential targets for antiviral drugs

被引:16
作者
Komazin, G
Ptak, RG
Emmer, BT
Townsend, LB
Drach, JC
机构
[1] Univ Michigan, Sch Dent, Dept Biol & Mat Sci, Ann Arbor, MI 48109 USA
[2] Univ Michigan, Coll Pharm, Interdept Grad Program Med Chem, Ann Arbor, MI 48109 USA
关键词
D O I
10.1081/NCN-120023123
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
引用
收藏
页码:1725 / 1727
页数:3
相关论文
共 4 条
[1]   Potent and selective inhibition of human cytomegalovirus replication by 1263W94, a benzimidazole L-riboside with a unique mode of action [J].
Biron, KK ;
Harvey, RJ ;
Chamberlain, SC ;
Good, SS ;
Smith, AA ;
Davis, MG ;
Talarico, CL ;
Miller, WH ;
Ferris, R ;
Dornsife, RE ;
Stanat, SC ;
Drach, JC ;
Townsend, LB ;
Koszalka, GW .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2002, 46 (08) :2365-2372
[2]   Cloning of the human cytomegalovirus (HCMV) genome as an infectious bacterial artificial chromosome in Escherichia coli:: a new approach for construction of HCMV mutants [J].
Borst, EM ;
Hahn, G ;
Koszinowski, UH ;
Messerle, M .
JOURNAL OF VIROLOGY, 1999, 73 (10) :8320-8329
[3]   Resistance of human cytomegalovirus to benzimidazole ribonucleosides maps to two open reading frames: UL89 and UL56 [J].
Krosky, PM ;
Underwood, MR ;
Turk, SR ;
Feng, KWH ;
Jain, RK ;
Ptak, RG ;
Westerman, AC ;
Biron, KK ;
Townsend, LB ;
Drach, JC .
JOURNAL OF VIROLOGY, 1998, 72 (06) :4721-4728
[4]   Inhibition of human cytomegalovirus DNA maturation by a benzimidazole ribonucleoside is mediated through the UL89 gene product [J].
Underwood, MR ;
Harvey, RJ ;
Stanat, SC ;
Hemphill, ML ;
Miller, T ;
Drach, JC ;
Townsend, LB ;
Biron, KK .
JOURNAL OF VIROLOGY, 1998, 72 (01) :717-725