Syntheses and evaluation of pyrido[2,3-d]pyrimidine-2,4-diones as PDE 4 inhibitors

被引：40

作者：

Nam, G

Yoon, CM

Kim, E

Rhee, CK

Kim, JH

Shin, JH

Kim, SH

机构：

[1] Korea Inst Sci & Technol, Biochem Res Ctr, Seoul 130650, South Korea

[2] Korea Univ, Coll Sci & Technol, Dept Chem, Chungnam 339700, South Korea

[3] Cheiljedang Corp, Kyonggi Do 467810, South Korea

[4] Seoul Natl Univ, Sch Chem & Mol Engn, Seoul 151742, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 05期

关键词：

D O I：

10.1016/S0960-894X(00)00681-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The syntheses and in vitro evaluation of a new series of pyrido[2,3-d]pyrimidine-2,4-diones bearing substituents at C-3 and/or C-4 positions on the pyridine ring are described. Some of these compounds, especially 51 and 6f, were found to be potent phosphodiesterase 4 (PDE 4) inhibitors exhibiting improved ratio of PDE 4 inhibitory activity:rolipram binding assay (RBA). (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：611 / 614

页数：4

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