The common lavender (Lavandula angustifolia Mill.) pectic polysaccharides modulate phagocytic leukocytes and intestinal Peyer's patch cells

被引：37

作者：

Georgiev, Yordan N. ^{[1
,2
]}

Paulsen, Berit S. ^{[3
]}

Kiyohara, Hiroaki ^{[4
]}

Ciz, Milan ^{[5
]}

Ognyanov, Manol H. ^{[1
,2
]}

Vasicek, Ondrej ^{[5
,9
]}

Rise, Frode ^{[6
]}

Denev, Petko N. ^{[1
,2
]}

Yamada, Haruki ^{[4
]}

Lojek, Antonin ^{[5
]}

Kussovski, Vesselin ^{[7
]}

Barsett, Hilde ^{[3
]}

Krastanov, Albert I. ^{[8
]}

Yanakieva, Irina Z. ^{[1
,2
]}

Kratchanova, Maria G. ^{[1
,2
]}

机构：

[1] Bulgarian Acad Sci, Inst Organ Chem, Ctr Phytochem, Lab Biologically Act Subst, 139 Ruski Blvd, BG-4000 Plovdiv, Bulgaria

[2] Innovat Technol Ctr Ltd, 20 Dr GM Dimitrov Str, BG-4000 Plovdiv, Bulgaria

[3] Univ Oslo, Sch Pharm, Dept Pharmaceut Chem, POB 1068 Blindern, NO-0316 Oslo, Norway

[4] Kitasato Univ, Kitasato Inst Life Sci, Dept Drug Discovery Sci, Minato Ku, 5-9-1 Shirokane, JP-1088641 Tokyo, Japan

[5] Czech Acad Sci, Inst Biophys, Dept Free Rad Pathophysiol, CZ-61265 Brno, Czech Republic

[6] Univ Oslo, Dept Chem, POB 1033 Blindern, NO-0315 Oslo, Norway

[7] Bulgarian Acad Sci, Stephan Angeloff Inst Microbiol, Acad G Bonchev Str,Bl 26, BG-1113 Sofia, Bulgaria

[8] Univ Food Technol, Dept Biotechnol, 26 Maritza Blvd, BG-4002 Plovdiv, Bulgaria

[9] St Annes Univ Hosp Brno, Ctr Biomol & Cellular Engn, Int Clin Res Ctr, 53 Pekarska, CZ-65691 Brno, Czech Republic

来源：

CARBOHYDRATE POLYMERS | 2017年 / 174卷

关键词：

Lavender; Pectin; Immunomodulation; Neutrophils; Macrophages; Peyer's patches; STRUCTURAL CHARACTERISTICS; COLORIMETRIC METHOD; URONIC-ACID; COMPLEMENT; QUANTIFICATION; ESTERIFICATION; RECEPTOR; PROTEIN; METHYL; ACETYL;

D O I：

10.1016/j.carbpol.2017.07.011

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Two pectic (chPS-L1, chPS-L2) and one polyphenolic (chPP-L) fractions were obtained from lavender flowers after boiling water extraction, exhaustive removing of alcohol-soluble molecules and SEC. chPS-L1 (52.4 kDa) contains mainly low-acetylated and high-methoxylated homogalacturonans (HG), and smaller rhamnogalacturonan (RG) I backbone fragments rich in 1,3,5-branched arabinan and arabinogalactan (AG) II side chains. chPS-L2 (21.8 kDa) contains predominantly similarly esterified HG, followed by RGI with AGII structures and RGII. The prevalence of catechin and epicatechin in chPP-L indicates that they form weak interactions with pectins. chPS-L1 and chPS-L2 enhanced beta(2)-integrin expression on neutrophils, inducing ROS generation and macrophage NO production. Both the effects on beta(2)-integrin and high complement fixation activity of chPS-L1 were proposed for its inhibitory action against PMA-and OZP-activated ROS formation. This, together with suppression of NO generation after co-stimulation with chPS-L1 and LPS, suggested anti-inflammatory activity of studied pectins. Lavender polysaccharides expressed intestinal Peyer's patch immunomodulating activity. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：948 / 959

页数：12

共 2 条

[1] Lavender (Lavandula angustifolia Mill.) industrial by-products as a source of polysaccharides
Marovska, Gergana
Vasileva, Ivelina
Petkova, Nadezhda
Ognyanov, Manol
Gandova, Vanya
Stoyanova, Albena
Merdzhanov, Pavel
Simitchiev, Apostol
Slavov, Anton
INDUSTRIAL CROPS AND PRODUCTS, 2022, 188
[2] Beta-D-(1 → 4)-galactan-containing side chains in RG-I regions of pectic polysaccharides from Biophytum petersianum Klotzsch contribute to expression of immunomodulating activity against intestinal Peyer's patch cells and macrophages
Gronhaug, Tom Erik
Kiyohara, Hiroaki
Sveaass, Anne
Diallo, Drissa
Yamada, Haruki
Paulsen, Bent Smestad
PHYTOCHEMISTRY, 2011, 72 (17) : 2139 - 2147

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