The common lavender (Lavandula angustifolia Mill.) pectic polysaccharides modulate phagocytic leukocytes and intestinal Peyer's patch cells

被引：37

作者：

Georgiev, Yordan N. ^{[1
,2
]}

Paulsen, Berit S. ^{[3
]}

Kiyohara, Hiroaki ^{[4
]}

Ciz, Milan ^{[5
]}

Ognyanov, Manol H. ^{[1
,2
]}

Vasicek, Ondrej ^{[5
,9
]}

Rise, Frode ^{[6
]}

Denev, Petko N. ^{[1
,2
]}

Yamada, Haruki ^{[4
]}

Lojek, Antonin ^{[5
]}

Kussovski, Vesselin ^{[7
]}

Barsett, Hilde ^{[3
]}

Krastanov, Albert I. ^{[8
]}

Yanakieva, Irina Z. ^{[1
,2
]}

Kratchanova, Maria G. ^{[1
,2
]}

机构：

[1] Bulgarian Acad Sci, Inst Organ Chem, Ctr Phytochem, Lab Biologically Act Subst, 139 Ruski Blvd, BG-4000 Plovdiv, Bulgaria

[2] Innovat Technol Ctr Ltd, 20 Dr GM Dimitrov Str, BG-4000 Plovdiv, Bulgaria

[3] Univ Oslo, Sch Pharm, Dept Pharmaceut Chem, POB 1068 Blindern, NO-0316 Oslo, Norway

[4] Kitasato Univ, Kitasato Inst Life Sci, Dept Drug Discovery Sci, Minato Ku, 5-9-1 Shirokane, JP-1088641 Tokyo, Japan

[5] Czech Acad Sci, Inst Biophys, Dept Free Rad Pathophysiol, CZ-61265 Brno, Czech Republic

[6] Univ Oslo, Dept Chem, POB 1033 Blindern, NO-0315 Oslo, Norway

[7] Bulgarian Acad Sci, Stephan Angeloff Inst Microbiol, Acad G Bonchev Str,Bl 26, BG-1113 Sofia, Bulgaria

[8] Univ Food Technol, Dept Biotechnol, 26 Maritza Blvd, BG-4002 Plovdiv, Bulgaria

[9] St Annes Univ Hosp Brno, Ctr Biomol & Cellular Engn, Int Clin Res Ctr, 53 Pekarska, CZ-65691 Brno, Czech Republic

来源：

CARBOHYDRATE POLYMERS | 2017年 / 174卷

关键词：

Lavender; Pectin; Immunomodulation; Neutrophils; Macrophages; Peyer's patches; STRUCTURAL CHARACTERISTICS; COLORIMETRIC METHOD; URONIC-ACID; COMPLEMENT; QUANTIFICATION; ESTERIFICATION; RECEPTOR; PROTEIN; METHYL; ACETYL;

D O I：

10.1016/j.carbpol.2017.07.011

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Two pectic (chPS-L1, chPS-L2) and one polyphenolic (chPP-L) fractions were obtained from lavender flowers after boiling water extraction, exhaustive removing of alcohol-soluble molecules and SEC. chPS-L1 (52.4 kDa) contains mainly low-acetylated and high-methoxylated homogalacturonans (HG), and smaller rhamnogalacturonan (RG) I backbone fragments rich in 1,3,5-branched arabinan and arabinogalactan (AG) II side chains. chPS-L2 (21.8 kDa) contains predominantly similarly esterified HG, followed by RGI with AGII structures and RGII. The prevalence of catechin and epicatechin in chPP-L indicates that they form weak interactions with pectins. chPS-L1 and chPS-L2 enhanced beta(2)-integrin expression on neutrophils, inducing ROS generation and macrophage NO production. Both the effects on beta(2)-integrin and high complement fixation activity of chPS-L1 were proposed for its inhibitory action against PMA-and OZP-activated ROS formation. This, together with suppression of NO generation after co-stimulation with chPS-L1 and LPS, suggested anti-inflammatory activity of studied pectins. Lavender polysaccharides expressed intestinal Peyer's patch immunomodulating activity. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：948 / 959

页数：12

共 59 条

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