Characterization of the logopenic variant of Primary Progressive Aphasia: A systematic review and meta-analysis

被引：22

作者：

Conca, Francesca ^{[1
]}

Esposito, Valentina ^{[1
]}

Giusto, Giada ^{[2
]}

Cappa, Stefano F. ^{[1
,2
]}

Catricala, Eleonora ^{[1
,2
]}

机构：

[1] IRCCS Mondino Fdn, Pavia, Italy

[2] ICoN Cognit Neurosci Ctr, Inst Adv Studies, IUSS, Pavia, Italy

来源：

AGEING RESEARCH REVIEWS | 2022年 / 82卷

关键词：

Primary Progressive Aphasia; Logopenic variant of Primary Progressive; Aphasia; Systematic review; Meta-analysis; Language; Neuropsychology; Neural biomarkers; WHITE-MATTER DAMAGE; ALZHEIMERS-DISEASE; SEMANTIC DEMENTIA; EPISODIC MEMORY; CLINICAL MARKER; NEURAL BASIS; CLASSIFICATION; LANGUAGE; PET; CRITERIA;

D O I：

10.1016/j.arr.2022.101760

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The linguistic and anatomical variability of the logopenic variant of Primary Progressive Aphasia (lv-PPA) as defined by current diagnostic criteria has been the topic of an intense debate. The present review and meta -analysis aims at characterizing the profile of lv-PPA, by a comprehensive analysis of the available literature on the neuropsychological, neuroimaging, electrophysiological, pathological, and genetic features of lv-PPA. We conducted a systematic bibliographic search, leading to the inclusion of 207 papers. Of them, 12 were used for the Anatomical Likelihood Estimation meta-analysis on grey matter revealed by magnetic resonance imaging data. The results suggest that the current guidelines outline a relatively consistent syndrome, characterized by a core set of linguistic and, to a lesser extent, non-linguistic deficits, mirroring the involvement of left temporal and parietal regions typically affected by Alzheimer Disease pathology. Variations of the lv-PPA profile are discussed in terms of heterogeneity of the neuropsychological instruments and the diagnostic criteria adopted.

引用

页数：23

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