Healthy lifestyle and risk of breast cancer among postmenopausal women in the European Prospective Investigation into Cancer and Nutrition cohort study

被引：83

作者：

McKenzie, Fiona ^{[1
,2
]}

Ferrari, Pietro ^{[1
]}

Freisling, Heinz ^{[1
]}

Chajes, Veronique ^{[1
]}

Rinaldi, Sabina ^{[1
]}

de Batlle, Jordi ^{[1
]}

Dahm, Christina C. ^{[3
]}

Overvad, Kim ^{[3
]}

Baglietto, Laura ^{[4
,5
]}

Dartois, Laureen ^{[6
,7
,8
]}

Dossus, Laure ^{[6
,7
,8
]}

Lagiou, Pagona ^{[9
,10
,11
]}

Trichopoulos, Dimitrios ^{[10
,11
,12
]}

Trichopoulou, Antonia ^{[12
]}

Krogh, Vittorio ^{[13
]}

Panico, Salvatore ^{[14
]}

Tumino, Rosario ^{[15
,16
]}

Rosso, Stefano ^{[17
]}

Bueno-de-Mesquita, H. B ^{[18
,19
,20
]}

May, Anne ^{[21
]}

Peeters, Petra H. ^{[20
,21
]}

Weiderpass, Elisabete ^{[22
,23
,24
,25
]}

Buckland, Genevieve ^{[26
]}

Sanchez, Maria-Jose ^{[27
,28
]}

Navarro, Carmen ^{[28
,29
,30
]}

Ardanaz, Eva ^{[28
,31
]}

Andersson, Anne ^{[32
]}

Sund, Malin ^{[33
]}

Ericson, Ulrika ^{[34
]}

Wirfalt, Elisabet ^{[34
]}

Key, Tim J. ^{[35
]}

Travis, Ruth C. ^{[35
]}

Gunter, Marc ^{[20
]}

Riboli, Elio ^{[20
]}

Vergnaud, Anne-Claire ^{[20
]}

Romieu, Isabelle ^{[1
]}

机构：

[1] IARC, F-69008 Lyon, France

[2] Massey Univ, Ctr Publ Hlth Res, Wellington, New Zealand

[3] Aarhus Univ, Dept Publ Hlth, Aarhus, Denmark

[4] Canc Council Victoria, Canc Epidemiol Ctr, Melbourne, Vic, Australia

[5] Univ Melbourne, Ctr Mol Environm Genet & Analyt Epidemiol, Melbourne, Vic, Australia

[6] INSERM, Ctr Res Epidemiol & Populat Hlth CESP, Villejuif, France

[7] Paris South Univ, UMRS 1018, Villejuif, France

[8] Inst Gustave Roussy, Villejuif, France

[9] Univ Athens, Sch Med, Dept Hyg Epidemiol & Med Stat, GR-11527 Athens, Greece

[10] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

[11] Acad Athens, Bur Epidemiol Res, Athens, Greece

[12] Hellen Hlth Fdn, Athens, Greece

[13] IRCCS Fdn, Natl Canc Inst, Epidemiol & Prevent Unit, Milan, Italy

[14] Univ Naples Federico II, Dept Clin Med & Surg, Naples, Italy

[15] Civile MP Arezzo Hosp, Canc Registry, Ragusa, Italy

[16] Civile MP Arezzo Hosp, Histopathol Unit, Ragusa, Italy

[17] Ctr Epidemiol & Prevent Oncol Piedmont, Piedmont Canc Registry, Turin, Italy

[18] Natl Inst Publ Hlth & Environm RIVM, Bilthoven, Netherlands

[19] Univ Med Ctr, Dept Gastroenterol & Hepatol, Utrecht, Netherlands

[20] Imperial Coll London, Sch Publ Hlth, London, England

[21] Univ Med Ctr Utrecht, Julius Ctr, Utrecht, Netherlands

[22] UiT Arctic Univ Norway, Fac Hlth Sci, Dept Community Med, Tromso, Norway

[23] Canc Registry Norway, Dept Res, Oslo, Norway

[24] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden

[25] Samfundet Folkhalsan, Helsinki, Finland

[26] Catalan Inst Oncol ICO IDIBELL, Unit Nutr Environm & Canc, Barcelona, Spain

[27] Granada Biohlth Res Inst Granada IBS, Andalusian Sch Publ Hlth, Granada, Spain

[28] CIBER Epidemiol & Publ Hlth CIBERESP, Madrid, Spain

[29] Murcia Reg Hlth Council, Dept Epidemiol, Murcia, Spain

[30] Univ Murcia, Dept Hlth & Social Sci, Murcia, Spain

[31] Navarre Publ Hlth Inst, Pamplona, Spain

[32] Umea Univ, Dept Radiat Sci, Oncol, Umea, Sweden

[33] Umea Univ, Dept Surg & Perioperat Sci, Umea, Sweden

[34] Lund Univ, Dept Clin Sci Malmo, S-22100 Lund, Sweden

[35] Univ Oxford, Canc Epidemiol Unit, Oxford OX1 2JD, England

来源：

INTERNATIONAL JOURNAL OF CANCER | 2015年 / 136卷 / 11期

基金：

英国医学研究理事会;

关键词：

breast cancer; healthy index; lifestyle; prospective studies; Europe; CORONARY-HEART-DISEASE; CIGARETTE-SMOKING; GLYCEMIC INDEX; DIETARY FIBER; MEXICAN WOMEN; FATTY-ACIDS; METAANALYSIS; ASSOCIATION; PREVENTION; ADHERENCE;

D O I：

10.1002/ijc.29315

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Breast cancer is the most common cancer among women and prevention strategies are needed to reduce incidence worldwide. A healthy lifestyle index score (HLIS) was generated to investigate the joint effect of modifiable lifestyle factors on postmenopausal breast cancer risk. The study included 242,918 postmenopausal women from the multinational European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, with detailed information on diet and lifestyle assessed at baseline. The HLIS was constructed from five factors (diet, physical activity, smoking, alcohol consumption and anthropometry) by assigning scores of 0-4 to categories of each component, for which higher values indicate healthier behaviours. Hazard ratios (HR) were estimated by Cox proportional regression models. During 10.9 years of median follow-up, 7,756 incident breast cancer cases were identified. There was a 3% lower risk of breast cancer per point increase of the HLIS. Breast cancer risk was inversely associated with a high HLIS when fourth versus second (reference) categories were compared [adjusted HR=0.74; 95% confidence interval (CI): 0.66-0.83]. The fourth versus the second category of the HLIS was associated with a lower risk for hormone receptor double positive (adjusted HR=0.81, 95% CI: 0.67-0.98) and hormone receptor double negative breast cancer (adjusted HR=0.60, 95% CI: 0.40-0.90). Findings suggest having a high score on an index of combined healthy behaviours reduces the risk of developing breast cancer among postmenopausal women. Programmes which engage women in long term health behaviours should be supported. What's new? How much does behavior really affect cancer risk? These authors set out to measure just that. First, they created a Healthy Lifestyle Index, which quantified five modifiable behaviors, such as smoking and physical activity. Then, using data from the European Prospective Investigation into Cancer and Nutrition (EPIC), they assigned each participant a score between 0 and 4 on each of the behaviors. It turned out that with each point added to a person's Healthy Lifestyle Index score, breast cancer risk fell by 3%, suggesting that public programs to help women maintain these behaviors could be worthwhile for cancer prevention.

引用

页码：2640 / 2648

页数：9

共 50 条

[1]

[Anonymous], 2010, GLOBOCAN 2008 CANC I

[2]

[Anonymous], 2007, Food, Nutrition, Physical Activity, and the Prevention of Cancer: a Global Perspective

[3]

[Anonymous], EUR J CLIN NUTR

[4] Dietary fiber and breast cancer risk: a systematic review and meta-analysis of prospective studies [J].

Aune, D. ;

Chan, D. S. M. ;

Greenwood, D. C. ;

Vieira, A. R. ;

Rosenblatt, D. A. Navarro ;

Vieira, R. ;

Norat, T. .

ANNALS OF ONCOLOGY, 2012, 23 (06) :1394-1402

[5] Familial breast cancer: collaborative reanalysis of individual data from 52 epidemiological studies including 58 209 women with breast cancer and 101 986 women without the disease [J].

Beral, V ;

Bull, D ;

Doll, R ;

Peto, R ;

Reeves, G .

LANCET, 2001, 358 (9291) :1389-1399

[6] Adherence to the mediterranean diet and risk of breast cancer in the European prospective investigation into cancer and nutrition cohort study [J].

Buckland, G. ;

Travier, N. ;

Cottet, V. ;

Gonzalez, C. A. ;

Lujan-Barroso, L. ;

Agudo, A. ;

Trichopoulou, A. ;

Lagiou, P. ;

Trichopoulos, D. ;

Peeters, P. H. ;

May, A. ;

Bueno-de-Mesquita, H. B. ;

Duijnhoven, F. J. Bvan ;

Key, T. J. ;

Allen, N. ;

Khaw, K. T. ;

Wareham, N. ;

Romieu, I. ;

McCormack, V. ;

Boutron-Ruault, M. ;

Clavel-Chapelon, F. ;

Panico, S. ;

Agnoli, C. ;

Palli, D. ;

Tumino, R. ;

Vineis, P. ;

Amiano, P. ;

Barricarte, A. ;

Rodriguez, L. ;

Sanchez, M. J. ;

Chirlaque, M. D. ;

Kaaks, R. ;

Teucher, B. ;

Boeing, H. ;

Bergmann, M. M. ;

Overvad, K. ;

Dahm, C. C. ;

Tjonneland, A. ;

Olsen, A. ;

Manjer, J. ;

Wirfalt, E. ;

Hallmans, G. ;

Johansson, I. ;

Lund, E. ;

Hjartaker, A. ;

Skeie, G. ;

Vergnaud, A. C. ;

Norat, T. ;

Romaguera, D. ;

Riboli, E. .

INTERNATIONAL JOURNAL OF CANCER, 2013, 132 (12) :2918-2927

[7]

Chajes V, 2013, MATURITAS

[8] Association between serum trans-monounsaturated fatty acids and breast cancer risk in the E3N-EPIC study [J].

Chajes, Veronique ;

Thiebaut, Anne C. M. ;

Rotival, Maxime ;

Gauthier, Estelle ;

Maillard, Virginie ;

Boutron-Ruault, Marie-Christine ;

Joulin, Virginie ;

Lenoir, Gilbert M. ;

Clavel-Chapelon, Francoise .

AMERICAN JOURNAL OF EPIDEMIOLOGY, 2008, 167 (11) :1312-1320

[9] Ecological-Level Associations Between Highly Processed Food Intakes and Plasma Phospholipid Elaidic Acid Concentrations: Results From a Cross-Sectional Study Within the European Prospective Investigation Into Cancer and Nutrition (EPIC) [J].

Chajes, Veronique ;

Biessy, Carine ;

Byrnes, Graham ;

Deharveng, Genevieve ;

Saadatian-Elahi, Mitra ;

Jenab, Mazda ;

Peeters, Petra H. M. ;

Ocke, Marga ;

Bueno-de-Mesquita, H. Bas ;

Johansson, Ingegerd ;

Hallmans, Goran ;

Manjer, Jonas ;

Wirfalt, Elisabet ;

Jakszyn, Paula ;

Gonzalez, Carlos A. ;

Huerta, Jose-Maria ;

Martinez, Carmen ;

Amiano, Pilar ;

Rodriguez Suarez, Laudina ;

Ardanaz, Eva ;

Tjonneland, Anne ;

Halkjaer, Jytte ;

Overvad, Kim ;

Jakobsen, Marianne Uhre ;

Berrino, Franco ;

Pala, Valeria ;

Palli, Domenico ;

Tumino, Rosario ;

Vineis, Paolo ;

de Magistris, Maria Santucci ;

Spencer, Elisabeth A. ;

Crowe, Francesca L. ;

Bingham, Sheila ;

Khaw, Kay-Tee ;

Linseisen, Jakob ;

Rohrmann, Sabine ;

Boeing, Heiner ;

Noeethlings, Ute ;

Olsen, Karina Standahl ;

Skeie, Guri ;

Lund, Eiliv ;

Trichopoulou, Antonia ;

Zilis, Dimosthenis ;

Oustoglou, Erifili ;

Clavel-Chapelon, Francoise ;

Riboli, Elio ;

Slimani, Nadia .

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, 2011, 63 (08) :1235-1250

[10] The fatty acid desaturation index of blood lipids, as a biomarker of hepatic stearoyl-CoA desaturase expression, is a predictive factor of breast cancer risk [J].

Chajes, Veronique ;

Joulin, Virginie ;

Clavel-Chapelon, Francoise .

CURRENT OPINION IN LIPIDOLOGY, 2011, 22 (01) :6-10

← 1 2 3 4 5 →