Connecting the Nucleus to the Cytoskeleton for Nuclear Positioning and Cell Migration

被引：17

作者：

Osorio, Daniel S. ^{[1
,2
]}

Gomes, Edgar R. ^{[1
,3
]}

机构：

[1] Univ Paris 06, INSERM, UMR S 787, Grp Myol,Fac Med Pitie Salpetriere, F-75634 Paris 13, France

[2] Univ Porto, Fac Med, PhD Program Biomed, P-4100 Oporto, Portugal

[3] Grp Hosp Pitie Salpetriere, Inst Myol, F-75634 Paris, France

来源：

CANCER BIOLOGY AND THE NUCLEAR ENVELOPE: RECENT ADVANCES MAY ELUCIDATE PAST PARADOXES | 2014年 / 773卷

基金：

欧盟地平线“2020”;

关键词：

Nuclear positioning; Centrosome reorientation; Cell migration; LINC complex; Nucleo-cytoskeletal connections; Nuclear envelope; Actin cytoskeleton; LINC COMPLEX; SELECTIVE STABILIZATION; MEMBRANE-PROTEINS; MAMMALIAN-CELLS; MITOTIC SPINDLE; LEADING-EDGE; KASH DOMAIN; ACTIN FLOW; TAN LINES; ENVELOPE;

D O I：

10.1007/978-1-4899-8032-8_23

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The position of the nucleus in the cytoplasm is a highly regulated process and is required for multiple cellular and developmental processes. Defects on different nuclear positioning events are associated with several pathologies such as muscle and nervous system disorders. In this chapter we describe the current knowledge on the mechanism of nuclear positioning. We discuss how the nucleus connects to the cytoskeleton by nesprins and SUN proteins, how this connection is regulated by Samp1, and how this connection is required for proper nuclear positioning. Furthermore, we discuss how nesprins, SUN, and Samp1 form transmembrane actin-associated nuclear (TAN) lines, novel nuclear envelope structures involved in force transduction during nuclear movement. Finally, we describe the recent evidences suggesting a role for the connection between the nucleus and the cytoskeleton in cancer.

引用

页码：505 / 520

页数：16

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