Malnutrition and Cachexia in Heart Failure

被引：202

作者：

Rahman, Adam ^{[1
,2
,3
]}

Jafry, Syed ^{[1
]}

Jeejeebhoy, Khursheed ^{[4
,5
,6
]}

Nagpal, A. Dave ^{[1
]}

Pisani, Barbara ^{[7
]}

Agarwala, Ravi ^{[8
]}

机构：

[1] Univ Western Ontario, London, ON, Canada

[2] Lawson Hlth Res Inst, London, ON, Canada

[3] Program Expt Med, London, ON, Canada

[4] Univ Toronto, Dept Med, Ancaster, ON, Canada

[5] Univ Toronto, Dept Nutr Sci, Ancaster, ON, Canada

[6] Univ Toronto, Dept Physiol, Ancaster, ON, Canada

[7] Wake Forest Sch Med, Cardiol Sect, Dept Med, Winston Salem, NC USA

[8] Wake Forest Sch Med, Sect Crit Care, Dept Anesthesia, Winston Salem, NC USA

来源：

JOURNAL OF PARENTERAL AND ENTERAL NUTRITION | 2016年 / 40卷 / 04期

关键词：

internal medicine; nutrition; nutrition assessment; minerals/trace elements; proteins; vitamins; nutrition support practice; outcomes research/quality; cardiac disease; research and diseases; critical care; organ transplantation; BODY-MASS INDEX; VENTRICULAR ASSIST DEVICE; CONVERTING-ENZYME-INHIBITORS; VITAMIN-D SUPPLEMENTATION; PROGNOSTIC IMPORTANCE; NUTRITION ASSESSMENT; INSULIN-RESISTANCE; DOUBLE-BLIND; MUSCLE; MANAGEMENT;

D O I：

10.1177/0148607114566854

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Heart failure is a growing public health concern. Advanced heart failure is frequently associated with severe muscle wasting, termed cardiac cachexia. This process is driven by systemic inflammation and tumor necrosis factor in a manner common to other forms of disease-related wasting seen with cancer or human immunodeficiency virus. A variable degree of malnutrition is often superimposed from poor nutrient intake. Cardiac cachexia significantly decreases quality of life and survival in patients with heart failure. This review outlines the evaluation of nutrition status in heart failure, explores the pathophysiology of cardiac cachexia, and discusses therapeutic interventions targeting wasting in these patients.

引用

页码：475 / 486

页数：12

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