Activation of PKCα is required for migration of C6 glioma cells

被引：0

作者：

Hu, Jian-Guo ^{[1
,2
]}

Wang, Xiao-Fei ^{[3
]}

Zhou, Jian-Sheng ^{[1
]}

Wang, Feng-Chao ^{[2
]}

Li, Xing-Wu ^{[2
]}

Lue, He-Zuo ^{[1
,4
]}

机构：

[1] Bengbu Med Coll, Anhui Key Lab Tissue Transplantat, Bengbu, Peoples R China

[2] Bengbu Med Coll, Affiliated Hosp 1, Dept Clin Lab Sci, Bengbu, Peoples R China

[3] Nantong Univ, Affiliated Hosp, Dept Clin Lab Sci, Nantong, Jiangsu, Peoples R China

[4] Bengbu Med Coll, Affiliated Hosp 1, Cent Lab, Bengbu, Peoples R China

来源：

ACTA NEUROBIOLOGIAE EXPERIMENTALIS | 2010年 / 70卷 / 03期

基金：

中国国家自然科学基金;

关键词：

PKC alpha; activation; C6 glioma cells; migration; signaling pathway; PROTEIN-KINASE-C; ISOENZYME EXPRESSION; CARCINOMA-CELLS; INTEGRIN; INVASION; BREAST; PHOSPHORYLATION; APOPTOSIS; MOTILITY;

D O I：

暂无

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The PKC signaling pathway has been implicated in diverse cellular functions. Here, we sought to investigate the role of PKC alpha/beta in C6 glioma cell migration. We found that both PKC alpha and PKC beta were expressed by C6 glioma cells, but only PKC alpha was markedly activated in serum-treated C6 cells. Go6976, a PKC alpha/beta specific inhibitor, was found to cause a dose-dependent reduction of PKC alpha activation and cell migration induced by serum in C6 cells. These results collectively indicated that the PKC alpha signaling pathway is necessary for glioma cell migration. Our findings may provide an insight into a better understanding to the malignant progression of gliomas.

引用

页码：239 / 245

页数：7

共 28 条

[1] Protein kinase C alpha expression in normal breast, ductal carcinoma in situ and invasive ductal carcinoma [J].

Ainsworth, PD ;

Winstanley, JHR ;

Pearson, JM ;

Bishop, HM ;

Garrod, DR .

EUROPEAN JOURNAL OF CANCER, 2004, 40 (15) :2269-2273

[2]

Amberger VR, 1998, CANCER RES, V58, P149

[3] STRESS signaling pathways that modulate cardiac myocyte apoptosis [J].

Baines, CP ;

Molkentin, JD .

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2005, 38 (01) :47-62

[4]

Bello L, 2004, CANC TREAT, V117, P263

[5] PKC alpha protein but not kinase activity is critical for glioma cell proliferation and survival [J].

Cameron, Angus J. ;

Procyk, Katarzyna J. ;

Leitges, Michael ;

Parker, Peter J. .

INTERNATIONAL JOURNAL OF CANCER, 2008, 123 (04) :769-779

[6] SAP regulates TH2 differentiation and PKC-θ-mediated activation of NF-κB1 [J].

Cannons, JL ;

Yu, LJ ;

Hill, B ;

Mijares, LA ;

Dombroski, D ;

Nichols, KE ;

Antonellis, A ;

Koretzky, GA ;

Gardner, K ;

Schwartzberg, PL .

IMMUNITY, 2004, 21 (05) :693-706

[7]

Chida K, 2003, CANCER RES, V63, P2404

[8] Medical progress: Brain tumors [J].

DeAngelis, LM .

NEW ENGLAND JOURNAL OF MEDICINE, 2001, 344 (02) :114-123

[9]

Engers R, 2000, BRIT J CANCER, V82, P1063

[10] Combined effects of radiotherapy and angiostatin gene therapy in glioma tumor model [J].

Griscelli, F ;

Li, H ;

Cheong, C ;

Opolon, P ;

Bennaceur-Griscelli, A ;

Vassal, G ;

Soria, J ;

Soria, C ;

Lu, H ;

Perricaudet, M ;

Yeh, P .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (12) :6698-6703

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