Cationic Peptidopolysaccharides Show Excellent Broad-Spectrum Antimicrobial Activities and High Selectivity

被引：245

作者：

Li, Peng ^{[1
]}

Zhou, Chuncai ^{[1
]}

Rayatpisheh, Shahrzad ^{[1
]}

Ye, Kai ^{[1
]}

Poon, Yin Fun ^{[1
]}

Hammond, Paula T. ^{[2
]}

Duan, Hongwei ^{[1
]}

Chan-Park, Mary B. ^{[1
]}

机构：

[1] Nanyang Technol Univ, Sch Chem & Biomed Engn, Singapore 637459, Singapore

[2] MIT, Dept Chem Engn, Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA

来源：

ADVANCED MATERIALS | 2012年 / 24卷 / 30期

关键词：

antimicrobial polymers; peptidopolysaccharide; chitosan; biomedical; biocompatible; HOST-DEFENSE PEPTIDES; HEMOLYTIC ACTIVITIES; STAPHYLOCOCCUS-AUREUS; POLYMERS; ANTIBACTERIAL; MEMBRANE; DESIGN; ACID; POLYMERIZATION; POLYPEPTIDES;

D O I：

10.1002/adma.201104186

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Facilely synthesized cationic peptidopolysaccharides, which have a bacterial peptidoglycan-mimetic structure, show outstanding broad-spectrum activities against clinically significant bacteria and fungi and low mammalian cytotoxicity. Their structural affinity with microbial cell-wall constituents promotes penetration to reach the cytoplasmic membrane resulting in excellent antimicrobial activity and high selectivity. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：4130 / 4137

页数：8

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