The Growth Hormone Receptor: Mechanism of Receptor Activation, Cell Signaling, and Physiological Aspects

被引：199

作者：

Dehkhoda, Farhad ^{[1
]}

Lee, Christine M. M. ^{[1
]}

Medina, Johan ^{[1
]}

Brooks, Andrew J. ^{[1
]}

机构：

[1] Univ Queensland, Diamantina Inst, Translat Res Inst, Brisbane, Qld, Australia

来源：

FRONTIERS IN ENDOCRINOLOGY | 2018年 / 9卷

基金：

英国医学研究理事会;

关键词：

growth hormone; growth hormone receptor; Janus kinase 2; Src family kinase; insulin-like growth factor 1; suppressor of cytokine signaling; COLONY-STIMULATING FACTOR; PROTEIN-TYROSINE-PHOSPHATASE; ACID-LABILE SUBUNIT; LONG-TERM TREATMENT; IMPROVES INSULIN SENSITIVITY; MESSENGER-RNA EXPRESSION; FACTOR-BINDING PROTEIN-3; SOCS-BOX MOTIF; FACTOR-I IGF-1; SKELETAL-MUSCLE;

D O I：

10.3389/fendo.2018.00035

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The growth hormone receptor (GHR), although most well known for regulating growth, has many other important biological functions including regulating metabolism and controlling physiological processes related to the hepatobiliary, cardiovascular, renal, gastrointestinal, and reproductive systems. In addition, growth hormone signaling is an important regulator of aging and plays a significant role in cancer development. Growth hormone activates the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) signaling pathway, and recent studies have provided a new understanding of the mechanism of JAK2 activation by growth hormone binding to its receptor. JAK2 activation is required for growth hormone-mediated activation of STAT1, STAT3, and STAT5, and the negative regulation of JAK-STAT signaling comprises an important step in the control of this signaling pathway. The GHR also activates the Src family kinase signaling pathway independent of JAK2. This review covers the molecular mechanisms of GHR activation and signal transduction as well as the physiological consequences of growth hormone signaling.

引用

页数：23

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