Algebraic Distribution of Segmental Duplication Lengths in Whole-Genome Sequence Self-Alignments

被引：21

作者：

Gao, Kun ^{[1
]}

Miller, Jonathan ^{[1
]}

机构：

[1] Okinawa Inst Sci & Technol, Phys & Biol Unit, Okinawa, Japan

来源：

PLOS ONE | 2011年 / 6卷 / 07期

关键词：

LONG-RANGE CORRELATIONS; DNA; MODEL; EVOLUTION; EXPANSION; ELEMENTS; RECOMBINATION; INSERTIONS; DELETIONS; PATTERNS;

D O I：

10.1371/journal.pone.0018464

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Distributions of duplicated sequences from genome self-alignment are characterized, including forward and backward alignments in bacteria and eukaryotes. A Markovian process without auto-correlation should generate an exponential distribution expected from local effects of point mutation and selection on localised function; however, the observed distributions show substantial deviation from exponential form - they are roughly algebraic instead - suggesting a novel kind of long-distance correlation that must be non-local in origin.

引用

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