Impaired clopidogrel antiplatelet effects and age: Young patients at risk

被引:7
作者
Polzin, Amin [1 ]
Kelm, Malte [1 ]
Zeus, Tobias [1 ]
机构
[1] Univ Dusseldorf, Med Ctr Dusseldorf, Div Cardiol Pulmonol & Vasc Med, Dusseldorf, Germany
关键词
Clopidogrel; HPR; HTPR; Age; PRI; PLATELET; PHARMACOKINETICS;
D O I
10.1016/j.ijcard.2015.03.320
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
[No abstract available]
引用
收藏
页码:216 / 218
页数:3
相关论文
共 5 条
[1]   Prasugrel 5 mg in the Very Elderly Attenuates Platelet Inhibition But Maintains Noninferiority to Prasugrel 10 mg in Nonelderly Patients [J].
Erlinge, David ;
Gurbel, Paul A. ;
James, Stefan ;
Lindahl, Tomas L. ;
Svensson, Peter ;
Ten Berg, Jurrien M. ;
Foley, David P. ;
Wagner, Henrik ;
Brown, Patricia B. ;
Luo, Junxiang ;
Zhou, Chunmei ;
Moser, Brian A. ;
Jakubowski, Joseph A. ;
Small, David S. ;
Winters, Kenneth J. ;
Angiolillo, Dominick J. .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2013, 62 (07) :577-583
[2]   Clopidogrel Pharmacokinetics and Pharmacodynamics Vary Widely Despite Exclusion or Control of Polymorphisms (CYP2C19, ABCB1, PON1), Noncompliance, Diet, Smoking, Co-Medications (Including Proton Pump Inhibitors), and Pre-Existent Variability in Platelet Function [J].
Frelinger, Andrew L., III ;
Bhatt, Deepak L. ;
Lee, Ronald D. ;
Mulford, Darcy J. ;
Wu, Jingtao ;
Nudurupati, Sai ;
Nigam, Anu ;
Lampa, Michael ;
Brooks, Julie K. ;
Barnard, Marc R. ;
Michelson, Alan D. .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2013, 61 (08) :872-879
[3]   Adenosine diphosphate-inducible platelet reactivity shows a pronounced age dependency in the initial phase of antiplatelet therapy with clopidogrel [J].
Gremmel, T. ;
Steiner, S. ;
Seidinger, D. ;
Koppensteiner, R. ;
Panzer, S. ;
Kopp, C. W. .
JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2010, 8 (01) :37-42
[4]   Clinical Pharmacokinetics of Clopidogrel and Its Metabolites in Patients with Cardiovascular Diseases [J].
Karazniewicz-Lada, Marta ;
Danielak, Dorota ;
Burchardt, Pawel ;
Kruszyna, Lukasz ;
Komosa, Anna ;
Lesiak, Maciej ;
Glowka, Franciszek .
CLINICAL PHARMACOKINETICS, 2014, 53 (02) :155-164
[5]   High on-thienopyridine platelet reactivity in elderly coronary patients: the SENIOR-PLATELET study [J].
Silvain, Johanne ;
Cayla, Guillaume ;
Hulot, Jean-Sebastien ;
Finzi, Jonathan ;
Kerneis, Mathieu ;
O'Connor, Stephen A. ;
Bellemain-Appaix, Anne ;
Barthelemy, Olivier ;
Beygui, Farzin ;
Collet, Jean-Philippe ;
Montalescot, Gilles .
EUROPEAN HEART JOURNAL, 2012, 33 (10) :1241-+