Bacillus Calmette-Guerin vaccination reduces the severity and progression of tuberculosis in badgers

被引：100

作者：

Chambers, Mark A. ^{[1
]}

Rogers, Fiona ^{[1
,2
]}

Delahay, Richard J. ^{[2
]}

Lesellier, Sandrine ^{[1
]}

Ashford, Roland ^{[1
]}

Dalley, Deanna ^{[1
]}

Gowtage, Sonya ^{[1
]}

Dave, Dipesh ^{[1
]}

Palmer, Si ^{[1
]}

Brewer, Jacky ^{[1
]}

Crawshaw, Timothy ^{[1
]}

Clifton-Hadley, Richard ^{[1
]}

Carter, Steve ^{[2
]}

Cheeseman, Chris ^{[2
]}

Hanks, Chris ^{[2
]}

Murray, Alistair ^{[2
]}

Palphramand, Kate ^{[2
]}

Pietravalle, Stephane ^{[2
]}

Smith, Graham C. ^{[2
]}

Tomlinson, Alexandra ^{[2
]}

Walker, Neil J. ^{[2
]}

Wilson, Gavin J. ^{[2
]}

Corner, Leigh A. L. ^{[3
]}

Rushton, Stephen P. ^{[4
]}

Shirley, Mark D. F. ^{[4
]}

Gettinby, George ^{[5
]}

McDonald, Robbie A. ^{[2
]}

Hewinson, R. Glyn ^{[1
]}

机构：

[1] Vet Labs Agcy, Addlestone KT15 3NB, Surrey, England

[2] Food & Environm Res Agcy, York YO41 1LZ, N Yorkshire, England

[3] Univ Coll Dublin, Sch Agr Food Sci & Vet Med, Dublin 2, Ireland

[4] Newcastle Univ, Sch Biol, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England

[5] Univ Strathclyde, Dept Math & Stat, Glasgow G1 1XH, Lanark, Scotland

来源：

PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES | 2011年 / 278卷 / 1713期

关键词：

bovine tuberculosis; vaccination; badger; wildlife; Bacillus Calmette-Guerin; MYCOBACTERIUM-BOVIS INFECTION; MELES-MELES; BCG VACCINATION; PROTECTIVE IMMUNITY; DISEASE; CATTLE; IMMUNOGENICITY; TRANSMISSION; DIAGNOSIS; PATHOLOGY;

D O I：

10.1098/rspb.2010.1953

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Control of bovine tuberculosis (TB) in cattle has proven particularly challenging where reservoirs of infection exist in wildlife populations. In Britain and Ireland, control is hampered by a reservoir of infection in Eurasian badgers (Meles meles). Badger culling has positive and negative effects on bovine TB in cattle and is difficult, costly and controversial. Here we show that Bacillus Calmette-Guerin (BCG) vaccination of captive badgers reduced the progression, severity and excretion of Mycobacterium bovis infection after experimental challenge. In a clinical field study, BCG vaccination of free-living badgers reduced the incidence of positive serological test results by 73.8 per cent. In common with other species, BCG did not appear to prevent infection of badgers subjected to experimental challenge, but did significantly reduce the overall disease burden. BCG vaccination of badgers could comprise an important component of a comprehensive programme of measures to control bovine TB in cattle.

引用

页码：1913 / 1920

页数：8

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