Bacillus Calmette-Guerin vaccination reduces the severity and progression of tuberculosis in badgers

被引：103

作者：

Chambers, Mark A. ^{[1
]}

Rogers, Fiona ^{[1
,2
]}

Delahay, Richard J. ^{[2
]}

Lesellier, Sandrine ^{[1
]}

Ashford, Roland ^{[1
]}

Dalley, Deanna ^{[1
]}

Gowtage, Sonya ^{[1
]}

Dave, Dipesh ^{[1
]}

Palmer, Si ^{[1
]}

Brewer, Jacky ^{[1
]}

Crawshaw, Timothy ^{[1
]}

Clifton-Hadley, Richard ^{[1
]}

Carter, Steve ^{[2
]}

Cheeseman, Chris ^{[2
]}

Hanks, Chris ^{[2
]}

Murray, Alistair ^{[2
]}

Palphramand, Kate ^{[2
]}

Pietravalle, Stephane ^{[2
]}

Smith, Graham C. ^{[2
]}

Tomlinson, Alexandra ^{[2
]}

Walker, Neil J. ^{[2
]}

Wilson, Gavin J. ^{[2
]}

Corner, Leigh A. L. ^{[3
]}

Rushton, Stephen P. ^{[4
]}

Shirley, Mark D. F. ^{[4
]}

Gettinby, George ^{[5
]}

McDonald, Robbie A. ^{[2
]}

Hewinson, R. Glyn ^{[1
]}

机构：

[1] Vet Labs Agcy, Addlestone KT15 3NB, Surrey, England

[2] Food & Environm Res Agcy, York YO41 1LZ, N Yorkshire, England

[3] Univ Coll Dublin, Sch Agr Food Sci & Vet Med, Dublin 2, Ireland

[4] Newcastle Univ, Sch Biol, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England

[5] Univ Strathclyde, Dept Math & Stat, Glasgow G1 1XH, Lanark, Scotland

来源：

PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES | 2011年 / 278卷 / 1713期

关键词：

bovine tuberculosis; vaccination; badger; wildlife; Bacillus Calmette-Guerin; MYCOBACTERIUM-BOVIS INFECTION; MELES-MELES; BCG VACCINATION; PROTECTIVE IMMUNITY; DISEASE; CATTLE; IMMUNOGENICITY; TRANSMISSION; DIAGNOSIS; PATHOLOGY;

D O I：

10.1098/rspb.2010.1953

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Control of bovine tuberculosis (TB) in cattle has proven particularly challenging where reservoirs of infection exist in wildlife populations. In Britain and Ireland, control is hampered by a reservoir of infection in Eurasian badgers (Meles meles). Badger culling has positive and negative effects on bovine TB in cattle and is difficult, costly and controversial. Here we show that Bacillus Calmette-Guerin (BCG) vaccination of captive badgers reduced the progression, severity and excretion of Mycobacterium bovis infection after experimental challenge. In a clinical field study, BCG vaccination of free-living badgers reduced the incidence of positive serological test results by 73.8 per cent. In common with other species, BCG did not appear to prevent infection of badgers subjected to experimental challenge, but did significantly reduce the overall disease burden. BCG vaccination of badgers could comprise an important component of a comprehensive programme of measures to control bovine TB in cattle.

引用

页码：1913 / 1920

页数：8

共 40 条

[31]

Sheppard A., 2005, EC IMPACT ASSESSMENT

[32] Effect of BCG vaccination on risk of Mycobacterium tuberculosis infection in children with household tuberculosis contact:: a prospective community-based study [J].

Soysal, A ;

Millington, KA ;

Bakir, M ;

Dosanjh, D ;

Aslan, Y ;

Deeks, JJ ;

Efe, S ;

Staveley, I ;

Ewer, K ;

Lalvani, A .

LANCET, 2005, 366 (9495) :1443-1451

[33] PROTECTIVE EFFECT OF BCG VACCINATION AS INDICATED BY AUTOPSY STUDIES [J].

SUTHERLAND, I ;

LINDGREN, I .

TUBERCLE, 1979, 60 (04) :225-231

[34] Oral vaccination reduces the incidence of tuberculosis in free-living brushtail possums [J].

Tompkins, D. M. ;

Ramsey, D. S. L. ;

Cross, M. L. ;

Aldwell, F. E. ;

de Lisle, G. W. ;

Buddle, B. M. .

PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 2009, 276 (1669) :2987-2995

[35] An ecological approach to preventing human infection: Vaccinating wild mouse reservoirs intervenes in the Lyme disease cycle [J].

Tsao, JI ;

Wootton, JT ;

Bunikis, J ;

Luna, MG ;

Fish, D ;

Barbour, AG .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (52) :18159-18164

[36] Correlation of ESAT-6-specific gamma interferon production with pathology in cattle following Mycobacterium bovis BCG vaccination against experimental bovine tuberculosis [J].

Vordermeier, HM ;

Chambers, MA ;

Cockle, PJ ;

Whelan, AO ;

Simmons, J ;

Hewinson, RG .

INFECTION AND IMMUNITY, 2002, 70 (06) :3026-3032

[37] Efficacy and immunogenicity of Mycobacterium bovis ΔRD1 against aerosol M. bovis infection in neonatal calves [J].

Waters, W. Ray ;

Palmer, Mitchell V. ;

Nonnecke, Brain J. ;

Thacker, Tyler C. ;

Scherer, Charles F. Capinos ;

Esters, D. Mark ;

Hewinson, R. Glyn ;

Vordermeier, H. Martin ;

Barnes, S. Whitney ;

Federe, Glenn C. ;

Walker, John R. ;

Glynne, Richard J. ;

Hsu, Tsungda ;

Weinrick, Brian ;

Biermann, Karolin ;

Larsen, Michelle H. ;

Jacobs, William R., Jr. .

VACCINE, 2009, 27 (08) :1201-1209

[38] BADGERS (MELES-MELES), CATTLE AND BOVINE TUBERCULOSIS (MYCOBACTERIUM-BOVIS) - A HYPOTHESIS TO EXPLAIN THE INFLUENCE OF HABITAT ON THE RISK OF DISEASE TRANSMISSION IN SOUTHWEST ENGLAND [J].

WHITE, PCL ;

BROWN, JA ;

HARRIS, S .

PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 1993, 253 (1338) :277-284

[39]

Wilesmith J.W., 1991, Revue Scientifique et Technique Office International des Epizooties, V10, P205

[40] A model of bovine tuberculosis in the badger Meles meles:: an evaluation of different vaccination strategies [J].

Wilkinson, D ;

Smith, GC ;

Delahay, RJ ;

Cheeseman, CL .

JOURNAL OF APPLIED ECOLOGY, 2004, 41 (03) :492-501

← 1 2 3 4 →