Functional Connectivity of the Amygdala Is Disrupted in Preschool-Aged Children With Autism Spectrum Disorder

被引:71
作者
Shen, Mark D. [1 ,2 ]
Li, Deana D. [1 ,2 ]
Keown, Christopher L. [3 ,4 ]
Lee, Aaron [1 ,2 ]
Johnson, Ryan T. [1 ,2 ]
Angkustsiri, Kathleen [1 ,2 ]
Rogers, Sally J. [1 ,2 ]
Muller, Ralph-Axel [3 ]
Amaral, David G. [1 ,2 ]
Nordahl, Christine Wu [1 ,2 ]
机构
[1] MIND Inst, Sacramento, CA USA
[2] Univ Calif Davis, Sch Med, Sacramento, CA 95817 USA
[3] San Diego State Univ, Brain Dev Imaging Lab, San Diego, CA 92182 USA
[4] Univ Calif San Diego, La Jolla, CA 92093 USA
关键词
autism; functional magnetic resonance imaging; neuroimaging; amygdala; development; DIAGNOSTIC OBSERVATION SCHEDULE; GLOBAL SIGNAL REGRESSION; RESTING STATE FMRI; YOUNG-CHILDREN; NEURODEVELOPMENTAL DISORDERS; MOTION ARTIFACT; WHITE-MATTER; HUMAN BRAIN; NETWORKS; SEVERITY;
D O I
10.1016/j.jaac.2016.05.020
中图分类号
B844 [发展心理学(人类心理学)];
学科分类号
040202 ;
摘要
Objective: The objective of this study was to determine whether functional connectivity of the amygdala is altered in preschool-age children with autism spectrum disorder (ASD) and to assess the clinical relevance of observed alterations in amygdala connectivity. Method: A resting-state functional connectivity magnetic resonance imaging study of the amygdala (and a parallel study of primary visual cortex) was conducted in 72 boys (mean age 3.5 years; n = 43 with ASD; n = 29 age-matched controls). Results: The ASD group showed significantly weaker connectivity between the amygdala and several brain regions involved in social communication and repetitive behaviors, including bilateral medial prefrontal cortex, temporal lobes, and striatum (p < .05, corrected). Weaker connectivity between the amygdala and frontal and temporal lobes was significantly correlated with increased autism severity in the ASD group (p < .05). In a parallel analysis examining the functional connectivity of primary visual cortex, the ASD group showed significantly weaker connectivity between visual cortex and sensorimotor regions (p < .05, corrected). Weaker connectivity between visual cortex and sensorimotor regions was not correlated with core autism symptoms, but instead was correlated with increased sensory hypersensitivity in the visual/auditory domain (p < .05). Conclusion: These findings indicate that preschool-age children with ASD have disrupted functional connectivity between the amygdala and regions of the brain important for social communication and language, which might be clinically relevant because weaker connectivity was associated with increased autism severity. Moreover, although amygdala connectivity was associated with behavioral domains that are diagnostic of ASD, altered connectivity of primary visual cortex was related to sensory hypersensitivity.
引用
收藏
页码:817 / 824
页数:8
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