Synthesis and Anticancer Activity of a Novel Series of Tetrazolo[1,5-a]quinoline Based 1,2,3-Triazole Derivatives

被引：12

作者：

Nagaraju, R. ^{[1
]}

Gopichand, K. ^{[1
]}

Rao, N. N. ^{[1
]}

Ganai, A. M. ^{[1
]}

Kishan, E. ^{[1
]}

Rao, P. Venkateswar ^{[1
]}

机构：

[1] Osmania Univ, Univ Coll Sci, Dept Chem, Hyderabad 500007, Telangana, India

来源：

RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2020年 / 90卷 / 02期

关键词：

tetrazole; 1; 2; 3-triazole; quinoline; chalcone; anticancer activity;

D O I：

10.1134/S1070363220020255

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report here the synthesis of a novel series of tetrazolo[1,5-a]quinoline based 1,2,3-triazoles from acetaniline via the Vilsmeier-Haack reaction, the Claisen-Schmidt condensation and 1,3-dipolar Click reaction. The newly synthesized compounds have been tested for their anticancer activity against a panel of three cell lines such as cervix (SiHa), brest (MDA-MB-231) and pancreatic carcinoma (PANC-1). Most of the synthesized compounds possess potent anticancer activity.

引用

页码：314 / 318

页数：5

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