Newer antidepressants - Beyond selective serotonin reuptake inhibitor antidepressants

Major depressive disorder in children and adolescents is a significant problem and is also predictive indicator of severe longterm difficulties. Although the current preference is to use SSRIs rather than TCAs in the treatment of child and adolescent depression, the hard evidence for efficacy from controlled studies is minimal. This article presents an overview of these compounds and leads into a discussion of the most common alternate antidepressants used by practitioners, as well as some newer developments.