Comparative analysis of extra-nodal NK/T-cell lymphoma and peripheral T-cell lymphoma: significant differences in clinical characteristics and prognosis

被引：56

作者：

Lim, Soon Thye ^{[1
]}

Hee, Siew Wan ^{[1
]}

Quek, Richard ^{[1
]}

Lim, Lay Cheng ^{[2
]}

Yap, Swee Peng ^{[3
]}

Loong, Er-Li ^{[3
]}

Sng, Ivy ^{[4
]}

Tan, Leonard Hwan-Cheong ^{[4
]}

Ang, Mei-Kim ^{[1
]}

Ngeow, Joanne ^{[1
]}

Tham, Chee-Kian ^{[1
]}

Ngo, Lynette ^{[1
]}

Tan, Min Han ^{[1
]}

Tao, Miriam ^{[1
]}

机构：

[1] Natl Canc Ctr, Dept Med Oncol, Singapore, Singapore

[2] Singapore Gen Hosp, Dept Hematol, Singapore 0316, Singapore

[3] Natl Canc Ctr, Dept Radiat Oncol, Singapore, Singapore

[4] Singapore Gen Hosp, Dept Pathol, Singapore 0316, Singapore

来源：

EUROPEAN JOURNAL OF HAEMATOLOGY | 2008年 / 80卷 / 01期

关键词：

peripheral T-cell lymphoma; extra-nodal NK/T-cell lymphoma; prognosis; characteristics;

D O I：

10.1111/j.1600-0609.2007.00978.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aim: We aimed to compare the frequencies, clinical characteristics, and prognostic factors of peripheral T-cell lymphoma (PTCL) vs. extra-nodal natural killer (NK)/T-cell lymphoma and to characterize the subtypes of extra-nodal NK/T-cell lymphoma. Methods: We reviewed 97 consecutive patients with PTCL and extra-nodal NKT lymphoma from 2000 to 2006. During this period, a total of 780 patients with malignant lymphomas were treated in our center. The diagnostic criteria used were based on the WHO classification system of malignant lymphomas. Results: Extra-nodal-NK/T-cell lymphoma and PTCL comprised 5.0% (39/780) and 7.4% (58/780) of all cases. Of the PTCL cases, histology was PTCL-NOS in 25, anaplastic large cell in 11, angioimmunoblastic T cell in 18 and other subtypes in four patients. Compared with PTCL, extra-nodal NK/T-cell lymphoma was associated with a significantly inferior rates of complete remission (33% vs. 53%, P = 0.05) and 3 yr overall survival (29.5% vs. 47.5%, P = 0.003). On multivariate analysis, extra-nodal NK/T-cell histology was independently associated with decreased survival. Further analysis into this subtype showed the nasal variant (n = 25) differed significantly from extra-nasal variant (n = 14) in terms of stage at presentation (stages III/IV, 36% vs. 79%), international prognostic index scores (high intermediate or high IPI scores, 24% vs. 64%), complete remission rates (48% vs. 7%), and median survival (10 months vs. 1 month, P < 0.0001). Conclusions: Extra-nodal NK/T-cell lymphoma was associated with a poorer prognosis compared with PTCL and is likely to comprise two distinct variants with different clinical behavior and prognosis.

引用

页码：55 / 60

页数：6