Design synthesis and biological evaluation of 3-substituted triazole derivatives

被引：11

作者：

Wang, Bao Gang ^{[1
,2
]}

Yu, Shi Chong ^{[1
]}

Chai, Xiao Yun ^{[1
]}

Yan, Yong Zheng ^{[1
]}

Hu, Hong Gang ^{[1
]}

Wu, Qiu Ye ^{[1
]}

机构：

[1] Second Mil Med Univ, Sch Pharm, Dept Organ Chem, Shanghai 200433, Peoples R China

[2] Second Mil Med Univ, Pharm Team, Shanghai 200433, Peoples R China

来源：

CHINESE CHEMICAL LETTERS | 2011年 / 22卷 / 05期

基金：

中国国家自然科学基金;

关键词：

Synthesis; Triazole; Antifungal activity; 1,3-Dipolar cycloaddition; ANTIFUNGAL ACTIVITY;

D O I：

10.1016/j.cclet.2010.11.029

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Based on the active site of lanosterol 14 alpha-demethylase of azole antifungal agents, sixteen 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-(N-n-butyl-N-1-substitutedbenzyl-4-methylene-1H-1,2,3-triazole)-2-propanols have been designed, synthesized and evaluated as antifungal agents. Results of preliminary antifungal tests against eight human pathogenic fungi in vitro showed that some of the compounds exhibited excellent activities with broad spectrum. (C) 2010 Hong Gang Hu. Published by Elsevier B.V, on behalf of Chinese Chemical Society. All rights reserved.

引用

页码：519 / 522

页数：4

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