Pitrakinra for asthma

被引：15

作者：

Antoniu, Sabina A. ^{[1
]}

Cojocaru, Ileana ^{[2
]}

机构：

[1] Gr T Popa Univ Med & Pharm Iasi, Pulm Dis Univ Hosp, Dept Med Pulm Dis 2, Iasi 700115, Romania

[2] Gr T Popa Univ Med & Pharm Iasi, Fac Pharm, Iasi 700115, Romania

来源：

EXPERT OPINION ON BIOLOGICAL THERAPY | 2010年 / 10卷 / 11期

关键词：

asthma; efficacy; IL-13; IL-4; IL-4R alpha; pitrakinra; safety; AIRWAY INFLAMMATION; ALLERGIC-ASTHMA; IL-13; INTERLEUKIN-13; MICE; FIBROBLASTS; HYPERRESPONSIVENESS; INHIBITION; CHALLENGE; RECEPTOR;

D O I：

10.1517/14712598.2010.524203

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Importance of the field: In asthma IL-4 and IL-13 have been demonstrated to play major pathogenic roles and therefore their blockade would potentially represent a plausible therapeutic approach. Areas covered in this review: Pitrakinra is a dual IL-4/IL-13 inhibitor currently under development for asthma and the existing preclinical and clinical data are discussed. What the reader will gain: Inhaled pitrakinra demonstrated a good anti-inflammatory potential and a good safety profile on a short-term basis but its place in asthma therapy is still to be found. Take home message: Specific anticytokine therapies might in the near future reshape asthma therapy.

引用

页码：1609 / 1615

页数：7

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