Vitamin D Deficiency Is Associated with Rapid Decline in Exercise Capacity in Male Patients with Chronic Obstructive Pulmonary Disease

被引：6

作者：

Kim, Changhwan ^{[1
,2
]}

Jung, Ji Ye ^{[2
,4
]}

Kim, Young Sam ^{[2
,4
]}

Lee, Jae Seung ^{[2
,3
]}

Rhee, Chin Kook ^{[2
,5
]}

Lee, Jin Hwa ^{[2
,6
]}

Lee, Ji-Hyun ^{[2
,7
]}

Kim, Tae-Hyung ^{[2
,8
]}

Lim, Seong Yong ^{[2
,9
]}

Sheen, Seung Soo ^{[2
,10
]}

Yoo, Kwang Ha ^{[2
,11
]}

Seo, Joon Beom ^{[12
,13
]}

Oh, Yeon-Mok ^{[2
,3
]}

Lee, Sang-Do ^{[2
,3
]}

Park, Yong Bum ^{[2
,14
]}

机构：

[1] Jeju Natl Univ Hosp, Dept Internal Med, Jeju, South Korea

[2] Univ Ulsan, Coll Med, Clin Res Ctr Chron Obstruct Airway Dis, Seoul, South Korea

[3] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Pulm & Crit Care Med, Seoul, South Korea

[4] Yonsei Univ, Coll Med, Dept Internal Med, Div Pulmonol, Seoul 120749, South Korea

[5] Catholic Univ Korea, Seoul St Marys Hosp, Coll Med, Dept Internal Med, Seoul, South Korea

[6] Ewha Womans Univ, Coll Med, Mokdong Hosp, Dept Internal Med, Seoul, South Korea

[7] CHA Univ, CHA Bundang Med Ctr, Dept Internal Med, Songnam, South Korea

[8] Hanyang Univ, Coll Med, Guri Hosp, Div Pulmonol,Dept Internal Med, Guri, South Korea

[9] Sungkyunkwan Univ, Sch Med, Kangbuk Samsung Hosp, Div Pulm & Crit Care Med,Dept Med, Seoul, South Korea

[10] Ajou Univ, Sch Med, Dept Pulm & Crit Care Med, Suwon 441749, South Korea

[11] Konkuk Univ, Sch Med, Dept Internal Med, Seoul, South Korea

[12] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Radiol, Seoul, South Korea

[13] Univ Ulsan, Coll Med, Asan Med Ctr, Res Inst Radiol, Seoul, South Korea

[14] Hallym Univ Kangdong, Sacred Heart Hosp, Dept Pulm & Crit Care Med, 445 Gil Dong, Seoul 134701, South Korea

来源：

RESPIRATION | 2016年 / 91卷 / 05期

关键词：

Chronic obstructive pulmonary disease; Vitamin D deficiency; Exercise capacity; Six-minute walk distance; LUNG-FUNCTION; SYSTEMIC INFLAMMATION; MUSCLE FUNCTION; WALK DISTANCE; COPD; DENSITY;

D O I：

10.1159/000445266

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Background: Vitamin D is suggested to play a role in airway and systemic inflammation in chronic obstructive pulmonary disease (COPD). Low serum 25-hydroxyvitamin D (25-OHD) levels have been suggested to be associated with lower lung function and poorer exercise capacity in COPD. Objectives: The main purpose of this study was to investigate the effects of vitamin D deficiency on the change in exercise capacity in male COPD patients. Methods: A total of 156 male subjects were selected from the Korean Obstructive Lung Disease cohort. Vitamin D deficiency was subdivided into three subgroups: mild, moderate, and severe deficiency groups. Rapid decline was defined as an annual rate of change in exercise capacity >= 17 m. Exercise capacity was assessed by 6-minute walk distance (6MWD). Results: Significant differences were observed in the serum levels of 25-OHD, the number of patients with vitamin D sufficiency, and moderate-to-severe deficiency between rapid decliners (n = 40) and non-rapid decliners (n = 116). No differences were found between the groups for age, smoking status, lung function, and 6MWD. Multivariate analysis showed that vitamin D deficiency was independently related to rapid decline in exercise capacity (p = 0.028). A statistically significant difference was observed among the subgroups of vitamin D deficiency in terms of the change in exercise capacity (p < 0.001). The annual decline in exercise capacity was prominent in the severe deficiency group (23.1 m/year). Conclusion: This study shows that vitamin D deficiency is associated with rapid decline in exercise capacity in male patients with COPD. (C) 2016 S. Karger AG, Basel

引用

页码：351 / 358

页数：8

共 31 条

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