Coffee drinking and hepatocellular carcinoma risk: A meta-analysis

被引:172
作者
Bravi, Francesca
Bosetti, Cristina
Tavani, Alessandra
Bagnardi, Vincenzo
Gallus, Silvano
Negri, Eva
Franceschi, Silvia
La Vecchia, Carlo
机构
[1] Ist Ric Farmacol Mario Negri, Lab Epidemiol, I-20157 Milan, Italy
[2] Univ Milan, Dipartimento Stat, I-20122 Milan, Italy
[3] Int Agcy Res Canc, F-69372 Lyon, France
[4] Univ Milan, Ist Stat Med & Biometria, I-20122 Milan, Italy
关键词
D O I
10.1002/hep.21708
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Several studies suggest an inverse relation between coffee drinking and risk of hepatocellular carcinoma (HCC). We conducted a meta-analysis of published studies on HCC that included quantitative information on coffee consumption. Ten studies were retrieved (2,260 HCC cases), including 6 case-control studies from southern Europe and Japan (1551 cases) and 4 cohort studies from Japan (709 cases). The summary relative risk (RR) for coffee drinkers versus non-drinkers was 0.54 (95% confidence interval [CI] 0.38-0.76) for case-control studies and 0.64 (95% CI 0.56-0.74) for cohort studies. The overall RR was 0.59 (95% CI 0.49-0-72), with significant heterogeneity between studies. The overall summary RR for low or moderate coffee drinkers was 0.70 (95% CI 0.57-0.85), and that for high drinkers was 0.45 (95% CI 0.38-0-53). The summary RR for an increase of 1 cup of coffee per day was 0.77 (95% CI 0.72-0.83) from case-control studies, 0.75 (95% CI 0.65-0.85) from cohort studies, and 0.77 (95% CI 0.72-0.82) overall. The consistency of an inverse relation between coffee drinking and HCC across study design and geographic areas weighs against a major role of bias or confounding. Coffee drinking has also been related to reduced risk of other liver diseases, thus suggesting a continuum of the favorable effect of coffee on liver function. However, subjects with liver conditions may selectively reduce their coffee consumption. Conclusion: The present analysis provides evidence that the inverse relation between coffee and HCC is real, though inference on causality remains open to discussion.
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页码:430 / 435
页数:6
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