P300 Wave Latency and Amplitude in Healthy Young Adults: A Normative Data

Background: Electrophysiological investigations are now very common in clinical investigations. Event-related potential (ERP) is also common in most electrophysiological recording in which P-300 is considered as the best indicator of psychological status. P-300 wave latency and amplitude are the best indicators of superior mental function status. Variability in P-300 has been demonstrated in diseases exhibiting cognitive abnormalities. Objective: The present study aimed to generate the normative data of P(300 )wave latency and amplitude in healthy young adults of 18-25 years age group in healthy young adults. Material and Methods: Hundred healthy young adults age (18-25 years) were analyzed for P300 using auditory oddball paradigm [Octopus NCV/EMG/EP-4 Channel Machine (Model name- CMEMG 01)], after taking anthropometric measurements (height, weight, and BMI). Whole data were collected after taking the willing consent of participants recruited for the study, and approval of Institute's ethics committee was taken before the start of study. Normally, distributive data were presented in the form of mean, standard deviation, and Pearson correlation was used to see check the correlation using MS-excel 2007. Results: The mean P-300 latency and amplitude were 281.38 +/- 33.39 ms and 4.53 +/- 1.67 mu V, respectively, in healthy young adults with mean age 19.81 +/- 1.80 years. With age the P300 latency was significantly positively correlated. Conclusions: This study results reflected normative data of P-300 wave latency and amplitude in healthy young adults of 18-25 years age group.