Tocilizumab in pediatric refractory status epilepticus and acute epilepsy: Experience in two patients

被引：31

作者：

Cantarin-Extremera, Veronica ^{[1
,2
]}

Jimenez-Legido, Maria ^{[1
]}

Duat-Rodriguez, Anna ^{[1
,2
]}

Garcia-Fernandez, Marta ^{[3
]}

Valentina Ortiz-Cabrera, Nelmar ^{[4
]}

Luz Ruiz-Falco-Rojas, Maria ^{[1
,2
]}

Gonzalez-Gutierrez-Solana, Luis ^{[1
,2
]}

机构：

[1] Hosp Infantil Univ Nino Jesus, Dept Neuropediat, Madrid, Spain

[2] Carlos III Hlth Inst, Networked Biomed Res Ctr Rare Dis CIBERER, Clin Grp Linked GCV14 ER 6, Madrid, Spain

[3] Hosp Infantil Univ Nino Jesus, Neurophysiol Dept, Video EEG Monitoring Unit, Madrid, Spain

[4] Hosp Infantil Univ Nino Jesus, Dept Clin Genet, Madrid, Spain

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2020年 / 340卷

关键词：

Epilepsy; FIRES/NORSE; Neuroinflammation; Interleukin (IL)-6; Tocilizumab; RELN; INTERLEUKIN-6; RECEPTOR; ADAPTIVE IMMUNITY; CYTOKINES; TARGETS; THERAPY; INNATE; PHASE;

D O I：

10.1016/j.jneuroim.2019.577142

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

There is growing evidence for inflammation as a cause and/or consequence of seizures in epilepsy as certain inflammatory biomarkers are elevated. Interleukin (IL)-6, with pro-inflammatory and epileptogenic effects, can perpetuate seizures. Clinical and experimental data support its involvement in acute refractory situations, with some cases responding to treatment with tocilizumab, a humanized monoclonal antibody against the IL-6 receptor. We describe 2 pediatric cases of refractory epilepsy with an abrupt debut responding to tocilizumab. Advances in the knowledge of inflammatory biomarkers involved in epilepsy and the targeted treatment could have important benefits, especially in cases that are refractory to usual treatments.

引用

页数：5

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