Enalaprilat-Mediated Activation of Kinin B1 Receptors and Vasodilation in the Rat Isolated Perfused Kidney

被引：3
|
作者：
Bautista-Perez, Rocio [1 ]
Arellano, Abraham [1 ]
Franco, Martha [1 ]
Osorio, Horacio [1 ]
Coronel, Israel [1 ]
机构：
[1] Inst Nacl Cardiol Ignacio Chavez, Dept Nephrol, Mexico City 14080, DF, Mexico
来源：
PHARMACOLOGY | 2011年 / 87卷 / 3-4期
关键词：
Angiotensin-converting enzyme inhibitors; Bradykinin; des-Arg(9)-BK; Diabetes; Kidney; Nitric oxide; ANGIOTENSIN-CONVERTING ENZYME; BRADYKININ B2 RECEPTOR; DIABETIC-NEPHROPATHY; B-2-KININ RECEPTORS; ENDOTHELIAL-CELLS; KALLIKREIN-KININ; NITRIC-OXIDE; EXPRESSION; MECHANISMS; INHIBITORS;
D O I：
10.1159/000324513
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The present study evaluated whether enalaprilat (the active form of enalapril, an angiotensin-converting enzyme inhibitor) activates B-1 receptors. We observed that the levels of B-1 receptor mRNA and protein expression were upregulated in the kidneys of diabetic rats. Bradykinin (BK)-induced renal vasodilation decreased in isolated perfused kidneys of diabetic rats, but des-Arg(9)-BK-induced renal vasodilation increased. Enalaprilat also produced vasodilation in the isolated perfused kidneys of control and diabetic rats. The response to des-Arg(9)-BK or enalaprilat was blocked by Lys-(des-Arg(9), Leu(8))-BK (a B-1 receptor antagonist) and N-nitro-L-arginine methyl ester (an inhibitor of nitric oxide synthase). These results suggest that enalaprilat activates B-1 receptors and stimulates the production of nitric oxide in the kidneys of both control and diabetic rats. Copyright (C) 2011 S. Karger AG, Basel
引用
收藏
页码：195 / 203
页数：9
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