Labdanecaryophyllic acid, a novel cytotoxic C35 terpenoid from Calocedrus macrolepis var. formosana

被引：6

作者：

Hsien, Chin-Lin ^{[1
,2
]}

Tseng, Mei-Hwei ^{[3
]}

Pan, Ryh-Nan ^{[2
]}

Chang, Jang-Yang ^{[4
,5
]}

Kuo, Ching-Chuan ^{[4
]}

Lee, Tzong-Huei ^{[6
]}

Kuo, Yueh-Hsiung ^{[1
,7
,8
]}

机构：

[1] Natl Taiwan Univ, Dept Chem, Taipei 106, Taiwan

[2] Taiwan Police Coll, Dept Disaster Management, Taipei 116, Taiwan

[3] Taipei Municipal Univ Educ, Dept Nat Sci, Taipei 106, Taiwan

[4] Natl Hlth Res Inst, Inst Canc Res, Taipei 114, Taiwan

[5] Natl Def Med Ctr, Triserv Gen Hosp, Dept Med, Div Hematol Oncol, Taipei 114, Taiwan

[6] Taipei Med Univ, Grad Inst Pharmacognosy, Taipei 110, Taiwan

[7] China Med Univ, Coll Pharm, Tsuzuki Inst Tradit Med, Taichung 404, Taiwan

[8] Acad Sinica, Agr Biotechnol Res Ctr, Taipei 115, Taiwan

来源：

TETRAHEDRON LETTERS | 2011年 / 52卷 / 04期

关键词：

Calocedrus macrolepis; Terpenoid; Cupressaceae; X-ray crystallography; LEAVES; BARK; LIGNANS;

D O I：

10.1016/j.tetlet.2010.11.101

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Chemical investigation of the bark of Calocedrus macrolepis var. formosana, an endemic tree in Taiwan, has led to the isolation of a novel terpenoid 1. Compound 1 with a rare C-35 skeleton constructed by a diterpene and a sesquiterpene moieties. Its structure was elucidated by spectroscopic interpretations. The anti-proliferation activity of 1 against human oral epidermoid carcinoma KB cells was evaluated, and the IC50 value was determined to be 9.2 +/- 0.4 mu M. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：515 / 517

页数：3

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