A physiological model of cerebral blood flow control

被引：55

作者：

Banaji, M

Tachtsidis, A

Delpy, D

Baigent, S

机构：

[1] UCL, Dept Med Phys & Bioengn, London WC1E 6BT, England

[2] UCL, Dept Math, London WC1E 6BT, England

来源：

MATHEMATICAL BIOSCIENCES | 2005年 / 194卷 / 02期

基金：

英国工程与自然科学研究理事会;

关键词：

human brain circulation; mathematical model; autoregulation;

D O I：

10.1016/j.mbs.2004.10.005

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The construction of a computational model of the human brain circulation is described. We combine an existing model of the biophysics of the circulatory system, a basic model of brain metabolic biochemistry, and a model of the functioning of vascular smooth muscle (VSM) into a single model. This represents a first attempt to understand how the numerous different feedback pathways by which cerebral blood flow is controlled interact with each other. The present work comprises the following: Descriptions of the physiology underlying the model; general comments on the processes by which this physiology is translated into mathematics; comments on parameter setting; and some simulation results. The simulations presented are preliminary, but show qualitative agreement between model behaviour and experimental results. (c) 2004 Elsevier Inc. All rights reserved.

引用

页码：125 / 173

页数：49

共 69 条

[1] Coherent and robust modulation of a metabolic network by cytoskeletal organization and dynamics [J].