Facile Assembly of H-Pyrazolo[5,1-α]isoquinolines via Silver Triflate-Catalyzed One-Pot Tandem Reaction of 2-Alkynyl-benzaldehyde, Sulfonohydrazide, and Ketone or Aldehyde

被引：67

作者：

Yu, Xingxin ^{[1
]}

Ye, Shengqing ^{[1
]}

Wu, Jie ^{[1
,2
]}

机构：

[1] Fudan Univ, Dept Chem, Shanghai 200433, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2010年 / 352卷 / 11-12期

关键词：

aldehydes; 2-alkynylbenzaldehydes; ketones, H-pyrazolo[5,1-alpha]isoquinolines, silver triflate; sulfonohydrazide; MULTICOMPONENT REACTIONS; ELECTROPHILIC CYCLIZATION; SUBSTITUTED ISOQUINOLINES; BENZODIAZEPINE-RECEPTOR; ORGANIC-SYNTHESIS; PALLADIUM; DERIVATIVES; DISCOVERY; PYRIDINES; 2-ALKYNYLBENZALDOXIME;

D O I：

10.1002/adsc.201000176

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A novel and efficient route for the generation of H-pyrazolo[5,1-alpha]isoquinolines via silver triflate-catalyzed one-pot tandem reaction of 2-alkynyl- benzaldehyde, sulfonohydrazide, and ketone or aldehyde is described. This reaction proceeds with good functional group tolerance under mild conditions with high efficiency and excellent selectivity

引用

页码：2050 / 2056

页数：7

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