Preliminary results from the French study on prenatal repair for fetal myelomeningoceles (the PRIUM study)

被引：11

作者：

Friszer, S. ^{[1
]}

Dhombres, F. ^{[1
]}

Di Rocco, F. ^{[2
]}

Rigouzzo, A. ^{[3
]}

Garel, C. ^{[4
]}

Guilbaud, L. ^{[1
]}

Forin, V. ^{[5
]}

Moutard, M. -L. ^{[6
]}

Zerah, M. ^{[2
]}

Jouannic, J. -M. ^{[1
]}

机构：

[1] Univ Paris 06, Hop Armand Trousseau, AP HP, Ctr Pluridisciplinaire Est Parisien,Serv Med Faet, 26 Ave Arnold Netter, F-75012 Paris, France

[2] Univ Paris 05, Hop Necker Enfants Malad, AP HP, Serv Neurochirurg Pediat, 49 Rue Sevres, F-75015 Paris, France

[3] Univ Paris 06, Hop Armand Trousseau, AP HP, Dept Anesthesie, 26 Ave Arnold Netter, F-75012 Paris, France

[4] Univ Paris 06, Hop Armand Trousseau, AP HP, Serv Radiopediat, 26 Ave Arnold Netter, F-75012 Paris, France

[5] Univ Paris 06, Hop Armand Trousseau, AP HP, Unite Pediat Med Phys & Readaptat, 26 Ave Arnold Netter, F-75012 Paris, France

[6] Univ Paris 06, Hop Armand Trousseau, AP HP, Serv Neuropediat, 26 Ave Arnold Netter, F-75012 Paris, France

来源：

JOURNAL DE GYNECOLOGIE OBSTETRIQUE ET BIOLOGIE DE LA REPRODUCTION | 2016年 / 45卷 / 07期

关键词：

Myelomeningocele; Prenatal diagnosis; Fetal surgery;

D O I：

10.1016/j.jgyn.2015.09.002

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Objectives. - To present the preliminary results of the PRIUM study, a French pilot study of prenatal repair for myelomeningoceles (MMC). Material and methods. - The fetal surgery for MMC is offered in cases of patients that did not opt for termination of pregnancy. Results. - Thirty-six patients were referred in an 18-month period. Eight patients were not eligible for prenatal repair. Another type of dysraphism was made in 6 cases (one spina-lipoma, 5 cases of limited dorsal myeloschisis). Twenty-two patients were eligible to fetal surgery. A prenatal repair was performed in three cases (14%). Four patients opted for a conventional postnatal treatment. Fifteen patients opted for termination of the pregnancy. Conclusion. - The establishment of a prenatal repair of MMC protocol in France was justified. The experience of the first 18 months of this study however suggests that only a limited number of couples will choose this procedure after specialized counseling in a reference center. (C) 2015 Elsevier Masson SAS. All rights reserved.

引用

页码：738 / 744

页数：7

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