Cerebrospinal fluid and plasma neurofilament light relate to abnormal cognition

被引：52

作者：

Osborn, Katie E. ^{[1
]}

Khan, Omair A. ^{[1
,2
]}

Kresge, Hailey A. ^{[1
]}

Bown, Corey W. ^{[1
]}

Liu, Dandan ^{[1
,2
]}

Moore, Elizabeth E. ^{[1
]}

Gifford, Katherine A. ^{[1
]}

Acosta, Lealani Mae Y. ^{[1
]}

Bell, Susan P. ^{[1
,3
,4
]}

Hohman, Timothy J. ^{[1
,5
]}

Blennow, Kaj ^{[6
,7
]}

Zetterberg, Henrik ^{[6
,7
,8
,9
]}

Jefferson, Angela L. ^{[1
]}

机构：

[1] Vanderbilt Univ, Med Ctr, Dept Neurol, Vanderbilt Memory & Alzheimers Ctr, Nashville, TN USA

[2] Vanderbilt Univ, Med Ctr, Dept Biostat, Nashville, TN USA

[3] Vanderbilt Univ, Med Ctr, Dept Med, Div Cardiovasc, Nashville, TN USA

[4] Vanderbilt Univ, Med Ctr, Dept Med, Div Geriatr Med, Nashville, TN USA

[5] Vanderbilt Univ, Med Ctr, Dept Med, Vanderbilt Genet Inst, Nashville, TN USA

[6] Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Dept Psychiat & Neurochem, Molndal, Sweden

[7] Sahlgrens Univ Hosp, Clin Neurochem Lab, Molndal, Sweden

[8] UCL Inst Neurol, Dept Neurodegenerat Dis, Queen Sq, London, England

[9] UCL, UK Dementia Res Inst, London, England

来源：

ALZHEIMER'S & DEMENTIA: DIAGNOSIS, ASSESSMENT & DISEASE MONITORING | 2019年 / 11卷 / 01期

基金：

欧洲研究理事会; 瑞典研究理事会;

关键词：

Neurofilament light; Cerebrospinal fluid; Plasma; Alzheimer's disease; Mild cognitive impairment; Cognition;

D O I：

10.1016/j.dadm.2019.08.008

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Introduction: Neuroaxonal damage may contribute to cognitive changes preceding clinical dementia. Accessible biomarkers are critical for detecting such damage. Methods: Plasma and cerebrospinal fluid (CSF) neurofilament light (NFL) were related to neuropsychological performance among Vanderbilt Memory & Aging Project participants (plasma n = 333, 73 +/- 7 years; CSF n 5 149, 72 +/- 6 years) ranging from normal cognition (NC) to mild cognitive impairment (MCI). Models adjusted for age, sex, race/ethnicity, education, apolipoprotein E epsilon 4 carriership, and Framingham Stroke Risk Profile. Results: Plasma NFL was related to all domains (P values <=.008) except processing speed (P values >=.09). CSF NFL was related to memory and language (P values <=.04). Interactions with cognitive diagnosis revealed widespread plasma associations, particularly in MCI participants, which were further supported in head-to-head comparison models. Discussion: Plasma and CSF NFL (reflecting neuroaxonal injury) relate to cognition among nondemented older adults albeit with small to medium effects. Plasma NFL shows particular promise as an accessible biomarker with relevance to cognition in MCI. (C) 2019 The Authors. Published by Elsevier Inc. on behalf of the Alzheimer's Association.

引用

页码：700 / 709

页数：10

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