Epigallocatechin 3-gallate: From green tea to cancer therapeutics

被引：142
作者：
Alam, Manzar [1 ]
Ali, Sabeeha [1 ]
Ashraf, Ghulam Md [2 ,3 ]
Bilgrami, Anwar L. [4 ]
Yadav, Dharmendra Kumar [5 ]
Hassan, Md Imtaiyaz [1 ]
机构：
[1] Jamia Millia Islamia, Ctr Interdisciplinary Res Basic Sci, New Delhi 110025, India
[2] King Abdulaziz Univ, King Fahd Med Res Ctr, Preclin Res Unit, Jeddah, Saudi Arabia
[3] King Abdulaziz Univ, Fac Appl Med Sci, Dept Med Lab Technol, Jeddah, Saudi Arabia
[4] King Abdulaziz Univ, Deanship Sci Res, Jeddah, Saudi Arabia
[5] Gachon Univ Med & Sci, Coll Pharm, Incheon 21924, South Korea
来源：
FOOD CHEMISTRY | 2022年 / 379卷
关键词：
Cancer therapy; Chemotherapy; Drug discovery; Epigallocatechin gallate; Green tea extracts; Natural products; Signaling pathways; KDA LAMININ RECEPTOR; GROWTH-FACTOR RECEPTOR; SQUAMOUS-CELL CARCINOMA; (-)-EPIGALLOCATECHIN-3-GALLATE INDUCES APOPTOSIS; PROMYELOCYTIC LEUKEMIA-CELLS; O-METHYLTRANSFERASE ACTIVITY; COLON-CANCER; ANTIOXIDANT PROPERTIES; DOWN-REGULATION; POLYPHENOL (-)-EPIGALLOCATECHIN-3-GALLATE;
D O I：
10.1016/j.foodchem.2022.132135
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Epigallocatechin 3-gallate (EGCG) possesses various biological functions, including anti-cancer and antiinflammatory properties. EGCG is an abundant polyphenolic component originating from green tea extract that has exhibited versatile bioactivities in combating several cancers. This review highlights the pharmacological features of EGCG and its therapeutic implications in cancer and other metabolic diseases. It modulates numerous signaling pathways, regulating cells' undesired survival and proliferation, thus imparting strong tumor chemopreventive and therapeutic effects. EGCG initiates cell death through the intrinsic pathway and causes inhibition of EGFR, STAT3, and ERK pathways in several cancers. EGCG alters and inhibits ERK1/2, NF-kappa B, and Akt-mediated signaling, altering the Bcl-2 family proteins ratio and activating caspases in tumor cells. This review focuses on anti-cancer, anti-oxidant, anti-inflammatory, anti-angiogenesis, and apoptotic effects of EGCG. We further highlighted the potential of EGCG in different types of cancer, emphasizing clinical trials formulations that further improve our understanding of the therapeutic management of cancer and inflammatory diseases.
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页数：16
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