Palladium-catalyzed difluoromethylthiolation of heteroaryl bromides, iodides, triflates and aryl iodides

被引：55

作者：

Wu, Jiang ^{[1
]}

Liu, Yafei ^{[1
]}

Lu, Changhui ^{[1
]}

Shen, Qilong ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, 345 Lingling Rd, Shanghai 200032, Peoples R China

来源：

CHEMICAL SCIENCE | 2016年 / 7卷 / 06期

基金：

中国国家自然科学基金;

关键词：

ALPHA-FLUORINATED ETHERS; MEDICINAL CHEMISTRY; DIRECT DIFLUOROMETHYLATION; C-NUCLEOPHILES; THIOETHERS; ARYLATION; REAGENT; HETEROCYCLES; COMPLEXES; HALIDES;

D O I：

10.1039/c6sc00082g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A palladium-catalyzed difluoromethylthiolation of heteroaryl halides and triflates under mild conditions was described. A vast range of heteroaryl halides such as pyridyl, quinolinyl, benzothiazolyl, thiophenyl, carbazolyl and pyazolyl halides could be difluoromethylthiolated efficiently, thus providing medicinal chemists with new tools for their search of new lead compounds for drug discovery. Likewise, aryl iodides were difluoromethylthiolated in high yields under a modified reaction condition.

引用

页码：3757 / 3762

页数：6

共 52 条

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