Neurogenic mechanisms in bladder and bowel ageing

被引:15
|
作者
Ranson, Richard N. [1 ]
Saffrey, M. Jill [2 ]
机构
[1] Northumbria Univ, Fac Hlth & Life Sci, Dept Appl Sci Biomed Sci, Newcastle Upon Tyne NE1 8ST, Tyne & Wear, England
[2] Open Univ, Dept Life Hlth & Chem Sci, Milton Keynes MK7 6AA, Bucks, England
基金
英国生物技术与生命科学研究理事会;
关键词
Ageing; Bladder; Bowel; Anal sphincter; Incontinence; Constipation; Autonomic nervous system; Enteric nervous system; LOWER URINARY-TRACT; AGE-RELATED-CHANGES; MAJOR PELVIC GANGLION; QUALITY-OF-LIFE; INTERNAL ANAL-SPHINCTER; GASTROINTESTINAL SMOOTH-MUSCLE; LUMBOSACRAL SPINAL-CORD; ENTERIC NERVOUS-SYSTEM; INTERSTITIAL-CELLS; FECAL INCONTINENCE;
D O I
10.1007/s10522-015-9554-3
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
The prevalence of both urinary and faecal incontinence, and also chronic constipation, increases with ageing and these conditions have a major impact on the quality of life of the elderly. Management of bladder and bowel dysfunction in the elderly is currently far from ideal and also carries a significant financial burden. Understanding how these changes occur is thus a major priority in biogerontology. The functions of the bladder and terminal bowel are regulated by complex neuronal networks. In particular neurons of the spinal cord and peripheral ganglia play a key role in regulating micturition and defaecation reflexes as well as promoting continence. In this review we discuss the evidence for ageing-induced neuronal dysfunction that might predispose to neurogenic forms of incontinence in the elderly.
引用
收藏
页码:265 / 284
页数:20
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