Neurogenic mechanisms in bladder and bowel ageing

被引：15

作者：

Ranson, Richard N. ^{[1
]}

Saffrey, M. Jill ^{[2
]}

机构：

[1] Northumbria Univ, Fac Hlth & Life Sci, Dept Appl Sci Biomed Sci, Newcastle Upon Tyne NE1 8ST, Tyne & Wear, England

[2] Open Univ, Dept Life Hlth & Chem Sci, Milton Keynes MK7 6AA, Bucks, England

来源：

BIOGERONTOLOGY | 2015年 / 16卷 / 02期

基金：

英国生物技术与生命科学研究理事会;

关键词：

Ageing; Bladder; Bowel; Anal sphincter; Incontinence; Constipation; Autonomic nervous system; Enteric nervous system; LOWER URINARY-TRACT; AGE-RELATED-CHANGES; MAJOR PELVIC GANGLION; QUALITY-OF-LIFE; INTERNAL ANAL-SPHINCTER; GASTROINTESTINAL SMOOTH-MUSCLE; LUMBOSACRAL SPINAL-CORD; ENTERIC NERVOUS-SYSTEM; INTERSTITIAL-CELLS; FECAL INCONTINENCE;

D O I：

10.1007/s10522-015-9554-3

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

The prevalence of both urinary and faecal incontinence, and also chronic constipation, increases with ageing and these conditions have a major impact on the quality of life of the elderly. Management of bladder and bowel dysfunction in the elderly is currently far from ideal and also carries a significant financial burden. Understanding how these changes occur is thus a major priority in biogerontology. The functions of the bladder and terminal bowel are regulated by complex neuronal networks. In particular neurons of the spinal cord and peripheral ganglia play a key role in regulating micturition and defaecation reflexes as well as promoting continence. In this review we discuss the evidence for ageing-induced neuronal dysfunction that might predispose to neurogenic forms of incontinence in the elderly.

引用

页码：265 / 284

页数：20

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