Hydrogel, a novel therapeutic and delivery strategy, in the treatment of intrauterine adhesions

被引：37

作者：

Lv, Houyi ^{[1
]}

Wu, Bingbing ^{[2
]}

Song, Jianyuan ^{[2
]}

Wu, Wei ^{[2
]}

Cai, Wangyu ^{[2
]}

Xu, Jian ^{[2
]}

机构：

[1] Zhejiang Univ, Womens Hosp, Dept Reprod Med, Sch Med, Hangzhou, Zhejiang, Peoples R China

[2] Zhejiang Univ, Affiliated Hosp 4, Sch Med, Yiwu, Zhejiang, Peoples R China

来源：

JOURNAL OF MATERIALS CHEMISTRY B | 2021年 / 9卷 / 33期

基金：

中国国家自然科学基金;

关键词：

MESENCHYMAL STEM-CELLS; PLATELET-RICH PLASMA; HYALURONIC-ACID GEL; CONTROLLED-RELEASE; ASHERMANS-SYNDROME; HYSTEROSCOPIC ADHESIOLYSIS; ENDOMETRIAL FIBROSIS; TRIBLOCK COPOLYMERS; COLLAGEN SCAFFOLDS; GROWTH-FACTOR;

D O I：

10.1039/d1tb01005k

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Intrauterine adhesions (IUAs) are caused by damage to the underlying lining of the endometrium. They' re related to disorder of endometrial repair. In recent years, hydrogels with controllable biological activity have been widely used for treating IUAs. They encapsulate estrogen, cytokines, cells, or exosomes, forming a delivery system to release therapeutic components for the treatment of IUAs. In addition, the hydrogel acting as a barrier can be degraded in the body automatically, reducing the risk of infection caused by secondary surgeries. In this review, we summarize the recent progress of hydrogels and their application in IUAs as both a novel alternative therapeutic and an artificial delivery strategy.

引用

页码：6536 / 6552

页数：17

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